ArticleUltrasound in medicine & biology2018
Evaluating Renal Transplant Status Using Viscoelastic Response (VisR) Ultrasound.
Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- VESTA: Machine Learning-Enabled Estimation of ViscoElastic Ratios from On-Axis Spatio-Temporal ARFI Features.bioRxiv : the preprint server for biology · 2026Article
- Diagnostic accuracy of MRI and US for identifying acute rejection after allogeneic kidney transplantation: a systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2026Article
- Sound touch viscosity imaging for chronic kidney disease staging: a novel biomarker for renal fibrosis.Quantitative imaging in medicine and surgery · 2025Article
- Differentiating medullary thyroid carcinoma from papillary thyroid carcinoma using ultrasound viscosity imaging: a preliminary study.BMC medical imaging · 2025Article
- A clinically applicable CKD diagnostic model derived from sound touch viscosity ultrasound and LASSO regression.Frontiers in bioengineering and biotechnology · 2025Article
- Prediction of acute rejection in renal allografts using shear-wave dispersion slope.European radiology · 2024Article
- Evaluation of Robustness of S-Transform Based Phase Velocity Estimation in Viscoelastic Phantoms and Renal Transplants.IEEE transactions on bio-medical engineering · 2024Article
- Feasibility of Phase Velocity Imaging Using Multi Frequency Oscillation-Shear Wave Elastography.IEEE transactions on bio-medical engineering · 2024Article
- Quantitative ultrasound for non-invasive evaluation of subclinical rejection in renal transplantation.European radiology · 2023Article
- Imaging of Single Transducer-Harmonic Motion Imaging-Derived Displacements at Several Oscillation Frequencies Simultaneously.IEEE transactions on medical imaging · 2022Article
- Feasibility of Harmonic Motion Imaging Using a Single Transducer: In Vivo Imaging of Breast Cancer in a Mouse Model and Human Subjects.IEEE transactions on medical imaging · 2021Article
- Electronic Point Spread Function Rotation Using a Three-Row Transducer for ARFI-Based Elastic Anisotropy Assessment: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Hydrophone Spatial Averaging Correction for Acoustic Exposure Measurements From Arrays-Part I: Theory and Impact on Diagnostic Safety Indexes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Local Phase Velocity Based Imaging of Viscoelastic Phantoms and Tissues.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Viscoelastic Response Ultrasound Derived Relative Elasticity and Relative Viscosity Reflect True Elasticity and Viscosity: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- Update on imaging-based diagnosis of acute renal allograft rejection.American journal of nuclear medicine and molecular imaging · 2019Review
- Renal Allograft Rejection: Noninvasive Ultrasound- and MRI-Based Diagnostics.Contrast media & molecular imaging · 2019Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Chronic kidney disease is most desirably and cost-effectively treated by renal transplantation, but graft survival is a major challenge. Although irreversible graft damage can be averted by timely treatment, intervention is delayed when early graft dysfunction goes undetected by standard clinical metrics. A more sensitive and specific parameter for delineating graft health could be the viscoelastic properties of the renal parenchyma, which are interrogated non-invasively by Viscoelastic Response (VisR) ultrasound, a new acoustic radiation force (ARF)-based imaging method. Assessing the performance of VisR imaging in delineating histologically confirmed renal transplant pathologies in vivo is the purpose of the study described here. VisR imaging was performed in patients with (n = 19) and without (n = 25) clinical indication for renal allograft biopsy. The median values of VisR outcome metrics (τ, relative elasticity [RE] and relative viscosity [RV]) were calculated in five regions of interest that were manually delineated in the parenchyma (outer, center and inner) and in the pelvis (outer and inner). The ratios of a given VisR metric for all possible region-of-interest combinations were calculated, and the corresponding ratios were statistically compared between biopsied patients subdivided by diagnostic categories versus non-biopsied, control allografts using the two-sample Wilcoxon test (p <0.05). Although τ ratios non-specifically differentiated allografts with vascular disease, tubular/interstitial scarring, chronic allograft nephropathy and glomerulonephritis from non-biopsied control allografts, RE distinguished only allografts with vascular disease and tubular/interstitial scarring, and RV distinguished only vascular disease. These results suggest that allografts with scarring and vascular disease can be identified using non-invasive VisR RE and RV metrics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.