Evidence map›Paper›PMID 29754660›Full record

ArticleAmerican heart journal2018

Predictors of intra-aortic balloon pump hemodynamic failure in non-acute myocardial infarction cardiogenic shock.

Steven Hsu, Swetha Kambhampati Thiruvengadam, Christopher M Sciortino, Stuart D Russell, Steven P Schulman

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05700617 (Myocardial Reserve in Advanced Heart Failure Patients), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05700617 early_phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Myocardial Reserve in Advanced Heart Failure Patients

TypeinterventionalSponsorUniversity of ChicagoRan2023 to 2027Enrolled5ConditionsHeart Failure, Cardiogenic ShockArms1:1 Randomization to receive milrinone
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Steven HsuDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: steven.hsu@jhmi.edu.
Swetha Kambhampati ThiruvengadamDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Christopher M SciortinoDivision of Cardiothoracic Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Stuart D RussellDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Steven P SchulmanDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins Medicine · USUniversity of Pittsburgh Medical Center · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

objectivesTo characterize patient profile and hemodynamic profile of those undergoing intra-aortic balloon pump (IABP) for cardiogenic shock and define predictors of hemodynamic failure of IABP support.

backgroundClinical characteristics of IABP support in cardiogenic shock not related to acute myocardial infarction (AMI) remain poorly characterized.

methodsWe retrospectively studied a cohort of 74 patients from 2010 to 2015 who underwent IABP insertion for cardiogenic shock complicating acute decompensated heart failure not due to AMI.

resultsIn the overall cohort, which consisted primarily of patients with chronic systolic heart failure (89%), IABP significantly augmented cardiac index and lowered systemic vascular resistance (P<.05). Despite this improvement, 28% of these patients died (24%) or require urgent escalation in mechanical circulatory support (MCS) (4%). Multivariable regression revealed that baseline left ventricular cardiac power index (LVCPI), a measure of LV power output derived from cardiac index and mean arterial pressure (P=.01), and history of ischemic cardiomyopathy (P=.003) were significantly associated with the composite adverse-event endpoint of death or urgent MCS escalation. An IABP Failure risk score using baseline LVCPI <0.28 W/m

conclusionDespite hemodynamic improvements with IABP support, patients with non-AMI cardiogenic shock still suffer poor outcomes. Patients with ischemic cardiomyopathy and low LVPCI fared significantly worse. These patients may warrant closer observation or earlier consideration of more advanced hemodynamic support.

Indexed as

Equipment FailureFemaleFollow-Up StudiesHeart FailureHemodynamicsHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMiddle AgedMyocardial InfarctionRetrospective StudiesShock, CardiogenicTreatment OutcomeUnited States

Identifiers

PMID29754660
PMCPMC5955398
OpenAlexW2774830857

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.