Trial reportRespiratory research2018
Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes.
Trial report in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Effects of Electronic Cigarettes on Lung Biology
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Pooled it
- Inflammatory and Carcinogenic Biomarker Signatures in E-Cigarette Users: A Comprehensive Meta-Analysis of ∼24,000 Adults.International journal of public health · 2025Pooled it
- A systematic review of the effects of e-cigarette use on lung function.NPJ primary care respiratory medicine · 2022Pooled it
- Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?World journal of methodology · 2024Trial
- Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial.Cancer prevention research (Philadelphia, Pa.) · 2020Trial
- Altered lung function in mice is a sensitive indicator of lung damage following 6 months of electronic nicotine delivery system aerosol exposure.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026Review
- A New Aerosol Respiratory Deposition Approach: Health Risks of Metals in Aerosols from Electronic Nicotine Delivery Systems and Heated Tobacco Products.Journal of aerosol science · 2026Article
- The respiratory epithelium in the era of vaping: insights fromEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- Patterns of Use of e-Cigarettes and Their Respiratory Effects: A Critical Umbrella Review.Tobacco use insights · 2025Review
- Circulating extracellular microvesicles associated with electronic cigarette use increase endothelial cell inflammation and reduce nitric oxide production.Experimental physiology · 2024Article
- Maternal use of electronic cigarettes and impact on offspring: a double-hit model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Article
- Current perspective on e-cigarette use and respiratory outcomes: mechanisms and messaging.Expert review of respiratory medicine · 2024Review
- The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes.The European respiratory journal · 2024Review
- Direct health implications of e-cigarette use: a systematic scoping review with evidence assessment.Frontiers in public health · 2024Article
- Safety and efficacy of e-cigarettes in those with atherosclerotic disease: a review.Open heart · 2023Review
- Characterizing risky alcohol use, cigarette smoking, e-cigarette use, and physical inactivity among cancer survivors in the USA-a cross-sectional study.Journal of cancer survivorship : research and practice · 2023Article
- Knowledge, Attitude, and Practice of E-Cigarettes of Adolescents and Adults in Saudi Arabia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Knowledge and Attitudes Toward E-cigarette Use: A Cross-Sectional Study From Saudi Arabia.Cureus · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about health risks associated with electronic cigarette (EC) use although EC are rising in popularity and have been advocated as a means to quit smoking cigarettes.
methodsTen never-smokers, without exposure history to tobacco products or EC, were assessed at baseline with questionnaire, chest X-ray, lung function, plasma levels of endothelial microparticles (EMP), and bronchoscopy to obtain small airway epithelium (SAE) and alveolar macrophages (AM). One week later, subjects inhaled 10 puffs of "Blu" brand EC, waited 30 min, then another 10 puff; n = 7 were randomized to EC with nicotine and n = 3 to EC without nicotine to assess biological responses in healthy, naive individuals.
resultsTwo hr. post-EC exposure, subjects were again assessed as at baseline. No significant changes in clinical parameters were observed. Biological changes were observed compared to baseline, including altered transcriptomes of SAE and AM for all subjects and elevated plasma EMP levels following inhalation of EC with nicotine.
conclusionsThis study provides in vivo human data demonstrating that acute inhalation of EC aerosols dysregulates normal human lung homeostasis in a limited cohort of healthy naïve individuals. These observations have implications to new EC users, nonsmokers exposed to secondhand EC aerosols and cigarette smokers using EC to quit smoking.
trial registrationClinicalTrials.gov NCT01776398 (registered 10/12/12), NCT02188511 (registered 7/2/14).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.