Evidence map›Paper›PMID 29754415›Full record

ReviewFEBS letters2018

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Jon M Fukuto, Louis J Ignarro, Peter Nagy, David A Wink, Christopher G Kevil, Martin Feelisch, Miriam M Cortese-Krott, Christopher L Bianco, Yoshito Kumagai, Adrian J Hobbs and 3 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 216 citations in OpenAlex.

  1. Review
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  13. Cancer prevention: past challenges and future directions.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  14. Review
  15. Review
  16. Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for HAngewandte Chemie (International ed. in English) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 5 countries.

Jon M FukutoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA, USA.
Louis J IgnarroDepartment of Molecular and Medical Pharmacology, Center for the Health Sciences, UCLA School of Medicine, Los Angeles, CA, USA.
Peter NagyDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, Hungary.
David A WinkTumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD, USA.
Christopher G KevilDepartment of Pathology, Louisiana Statue University Health Sciences Center, Shreveport, LA, USA.
Martin FeelischNIHR Southampton Biomedical Research Center, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Miriam M Cortese-KrottCardiovascular Research Laboratory, Department of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany.
Christopher L BiancoCardiovascular Research Laboratory, Department of Cardiology, Pneumology and Angiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany.
Yoshito KumagaiEnvironmental Biology Section, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Adrian J HobbsWilliam Harvey Research Institute, Bart & London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK.
Joseph LinDepartment of Biology, Sonoma State University, Rohnert Park, CA, USA.
Tomoaki IdaDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takaaki AkaikeDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Heinrich Heine University Düsseldorf · DESonoma State University · USTohoku University · JPLouisiana State University Health Sciences Center Shreveport · USNational Cancer Institute · USNational Institute of Oncology · HUOklahoma State University Center for Health Sciences · USUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Tsukuba · JPWilliam Harvey Research Institute · GB

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Vesna Tesic · 2018 to 2026
$23.6M
CHemical Biology of Nitroxyl (HNO)ZIABC011190 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$2.9M
NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

The chemical biology of thiols (RSH, e.g., cysteine and cysteine-containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS

Indexed as

AnimalsCysteineHumansHydrogen SulfideOxidation-ReductionSignal TransductionSulfhydryl CompoundsSulfidesCysteineHydrogen SulfidepersulfidesSulfhydryl CompoundsSulfidescysteine persulfideshydropersulfidestranslational polysulfidation

Identifiers

PMID29754415
PMCPMC6033183
OpenAlexW2802985983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.