ArticleIntensive care medicine2019
The ten pitfalls of lactate clearance in sepsis.
Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04693923 (Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients), which is not on this map. Cited by 146 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow
Who cites it
146 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis.Critical care (London, England) · 2023Pooled it
- Pooled it
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial.Intensive care medicine · 2024Trial
- Hyperlactatemia associated with diabetic ketoacidosis in pediatric intensive care unit.BMC endocrine disorders · 2021Trial
- Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial.European journal of clinical pharmacology · 2020Trial
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- ICU-acquired acute kidney injury in critically ill adults: a retrospective cohort study of risk factors and KDIGO stage dynamics in a Brazilian ICU.Renal failure · 2026Article
- Bedside monitoring of the vascular response to norepinephrine in early septic shock: VNERi trajectories and comparison with dynamic clinical measures.Journal of clinical monitoring and computing · 2026Article
- The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.Brain, behavior, & immunity - health · 2026Review
- Type B Lactic Acidosis: Diagnosis, Etiology and Treatment - An Educational Review.Cardiology research · 2026Review
- A Temperature-Robust Non-Enzymatic Lactate Sensor Based on Graphene Fiber Composite Electrodes.Nanomaterials (Basel, Switzerland) · 2026Article
- Twenty-five years of septic shock hemodynamic resuscitation trials: a conceptual perspective.Critical care (London, England) · 2026Review
- Association between the lactate to creatinine ratio and hospital mortality in patients with pediatric sepsis: a cohort study.Pediatric research · 2026Article
- Hyperlactatemia in sepsis and shock: a renal metabolic perspective.Critical care (London, England) · 2026Review
- Metabolic and lipidomic stability in EDTA plasma from hospitalized patients: impact of refrigerated storage time and additional freeze-thaw cycle.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Papaverine Mitigates Acute Kidney Injury in Feces-Induced Polymicrobial Sepsis Through Regulation of the HMGB1-RAGE Axis.Medicina (Kaunas, Lithuania) · 2026Article
- Association of ACAG with short-term mortality in liver failure patients: a retrospective analysis based on the MIMIC-IV database.Scientific reports · 2026Article
- Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials.Clinics (Sao Paulo, Brazil) · 2026Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.