Evidence map›Paper›PMID 29754286›Full record

SynthesisDiabetologia2018

Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes.

David Houghton, Timothy Hardy, Christopher Stewart, Linda Errington, Christopher P Day, Michael I Trenell, Leah Avery

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 8 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

David HoughtonInstitute of Cellular Medicine, 4th Floor William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. david.houghton@ncl.ac.uk.ORCID 0000-0002-0293-3416
Timothy HardyInstitute of Cellular Medicine, 4th Floor William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Christopher StewartDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Linda ErringtonFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Christopher P DayInstitute of Cellular Medicine, 4th Floor William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Michael I TrenellInstitute of Cellular Medicine, 4th Floor William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Leah AveryInstitute of Cellular Medicine, 4th Floor William Leech Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Newcastle University · GBFreeman Hospital · GBBaylor College of Medicine · US

Funding

Department of Health SRF-2011-04-017Medical Research Council MR/L016354/1
6 · The paper itself

Abstract

aims/hypothesisDespite improved understanding of the pathophysiology of type 2 diabetes mellitus, explanations for individual variability in disease progression and response to treatment are incomplete. The gut microbiota has been linked to the pathophysiology of type 2 diabetes mellitus and may account for this variability. We conducted a systematic review to assess the effectiveness of dietary and physical activity/exercise interventions in modulating the gut microbiota and improving glucose control in adults with type 2 diabetes mellitus.

methodsA systematic search was conducted to identify studies reporting on the effect of dietary and physical activity/exercise interventions on the gut microbiota and glucose control in individuals with a confirmed diagnosis of type 2 diabetes mellitus. Study characteristics, methodological quality and details relating to interventions were captured using a data-extraction form. Meta-analyses were conducted where sufficient data were available, and other results were reported narratively.

resultsEight studies met the eligibility criteria of the systematic review. No studies were found that reported on the effects of physical activity/exercise on the gut microbiota and glucose control. However, studies reporting on dietary interventions showed that such interventions were associated with modifications to the composition and diversity of the gut microbiota. There was a statistically significant improvement in HbA CONCLUSIONS/

interpretationDietary intervention was found to modulate the gut microbiota and improve glucose control in individuals with type 2 diabetes. Although the results of the included studies are encouraging, this review highlights the need for further well-conducted interventional studies to inform the clinical use of dietary interventions targeting the gut microbiota.

Indexed as

Diabetes Mellitus, Type 2ExerciseGastrointestinal MicrobiomeGlycated HemoglobinHumansGlycated Hemoglobinhemoglobin A1c protein, humanDietExerciseGut microbiotaInterventionPhysical activitySystematic reviewType 2 diabetes

Identifiers

PMID29754286
PMCPMC6061157
OpenAlexW2802229234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.