Evidence map›Paper›PMID 29754268›Full record

ArticleAIDS and behavior2018

The Role of Social Relationships in PrEP Uptake and Use Among Transgender Women and Men Who Have Sex with Men.

Megha L Mehrotra, K Rivet Amico, Vanessa McMahan, David V Glidden, Patricia Defechereux, Juan V Guanira, Robert M Grant

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Megha L MehrotraJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA, 94158, USA. megha.mehrotra@ucsf.edu.
K Rivet AmicoSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Vanessa McMahanUniversity of Washington, Seattle, WA, USA.
David V GliddenUniversity of California, San Francisco, CA, USA.
Patricia DefechereuxJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA, 94158, USA.
Juan V GuaniraInvestigaciones Médicas en Salud, Lima, Peru.
Robert M GrantJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA, 94158, USA. Robert.grant@ucsf.edu.
Gladstone Institutes · USUniversity of California, San Francisco · USEsSALUD · PEUniversity of Michigan–Ann Arbor · USUniversity of Washington · US

Funding

Chemoprophylaxis for HIV Prevention in Men SupplementU01AI064002 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GRANT, ROBERT M. · 2005 to 2011
$41.3M
Chemoprophylaxis and HIV-Host InteractionsR01AI062333 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GRANT, ROBERT M. · 2004 to 2011
$6.2M
Chemoprophylaxis and HIV Host InteractionsR01AI118575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANT, ROBERT M. · 2015 to 2019
$2.9M
Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure ProphylaxisR03AI122908 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLIDDEN, DAVID V. · 2016 to 2017
$159k
National Institute of Allergy and Infectious Diseases R01 AI062333National Institute of Allergy and Infectious Diseases R01 AI118575National Institute of Allergy and Infectious Diseases U01 AI064002NIAID NIH HHS R01 AI062333NIAID NIH HHS R01 AI118575NIAID NIH HHS R03 AI122908NIAID NIH HHS U01 AI064002
6 · The paper itself

Abstract

Qualitative studies suggest that social relationships play an important role in HIV pre-exposure prophylaxis (PrEP) use, but there have been few quantitative assessments of the role of social relationships in PrEP uptake or adherence. We examined the association between disclosure of study participation or LGBT identity and PrEP use in the 1603 HIV-negative participants enrolled in the iPrEx OLE study. We also evaluated the association between LGBT social group involvement and PrEP use. Study participation disclosure to parents and LGBT identity disclosure to anyone in a participant's social network were associated with greater PrEP uptake. Study participation disclosure to partners was associated with higher probability of having protective PrEP drug concentrations compared [risk difference 0.15 95% CI (0.01, 0.30)]. For each additional type of LGBT organization a participant was involved in, the probability of PrEP uptake and having protective drug concentrations increased by 0.04 [95% CI (0.03, 0.06)] and 0.04 (95% CI (0.02, 0.07)] respectively. Overall, social context was associated with PrEP use in iPrEx OLE, and should be taken into consideration when designing future PrEP implementation programs.

Indexed as

Medication AdherencePre-Exposure ProphylaxisSexual PartnersAdultAnti-HIV AgentsFemaleHIV InfectionsHomosexuality, MaleHumansInterviews as TopicMaleQualitative ResearchSafe SexSocial IdentificationSocial NetworkingTransgender PersonsAnti-HIV AgentsAdherenceDisclosurePre-exposure prophylaxisSocial integrationSocial relationships

Identifiers

PMID29754268
PMCPMC6492931
OpenAlexW2800274024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.