Evidence map›Paper›PMID 29754071›Full record

ArticleNeoplasia (New York, N.Y.)2018

Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue.

Elizabeth A Loughran, Annemarie K Leonard, Tyvette S Hilliard, Ryan C Phan, Madeleine G Yemc, Elizabeth Harper, Emma Sheedy, Yuliya Klymenko, Marwa Asem, Yueying Liu and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  9. Article
  10. Regulation of Age-Related Lipid Metabolism in Ovarian Cancer.International journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
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  16. Review
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  18. Article
  19. In Vivo and Ex Vivo Analysis of Omental Adhesion in Ovarian Cancer.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Elizabeth A LoughranDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Annemarie K LeonardDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Tyvette S HilliardDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Ryan C PhanHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Madeleine G YemcHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Elizabeth HarperDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Emma SheedyHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Yuliya KlymenkoHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN.
Marwa AsemDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Yueying LiuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Jing YangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Jeff JohnsonDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Laura TarwaterHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Zonggao ShiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Matthew LeevyHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN.
Matthew J RavosaHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN; Department of Anthropology, University of Notre Dame, Notre Dame, IN.
M Sharon StackDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN. Electronic address: sstack@nd.edu.
University of Notre Dame · US

Funding

Receptor Cross-Talk in Early Metastatic DisseminationR01CA109545 · NCI · UNIVERSITY OF NOTRE DAME · PI STACK, MARY SHARON · 2006 to 2022
$4.3M
REGULATION OF OVARIAN CARCINOMA PROTEINASESR01CA086984 · NCI · UNIVERSITY OF NOTRE DAME · PI STACK, MARY SHARON · 2000 to 2014
$3.8M
The Impact of Maternal Obesity on the Reprogramming of the Metastatic MicroenvironmentK01CA218305 · NCI · UNIVERSITY OF NOTRE DAME · PI HILLIARD, TYVETTE · 2017 to 2021
$517k
NCI NIH HHS K01 CA218305NCI NIH HHS R01 CA086984NCI NIH HHS R01 CA109545
6 · The paper itself

Abstract

Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis. Here we report that the aged host is more susceptible to metastatic success using two murine syngeneic allograft models of ovarian cancer metastasis. This age-related increase in metastatic tumor burden corresponds with an increase in tumor infiltrating lymphocytes (TILs) in tumor-bearing mice and alteration of B cell-related pathways in gonadal adipose tissue. Based on this work, further studies elucidating the status of B cell TILs in mouse models of metastasis and human tumors in the context of aging are warranted.

Indexed as

Adipose TissueAdultAgedAgingAllograftsAnimalsCell LineFemaleHumansLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMiddle AgedNeoplasm MetastasisOvarian NeoplasmsPrognosis

Identifiers

PMID29754071
PMCPMC5994778
OpenAlexW2799399097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.