Evidence map›Paper›PMID 29754027›Full record

ArticleEnvironment international2018

Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel.

Ronit Machtinger, Tamar Berman, Michal Adir, Abdallah Mansur, Andrea A Baccarelli, Catherine Racowsky, Antonia M Calafat, Russ Hauser, Ravit Nahum

Open access · greenAbstract read
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
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  11. Placental outcomes of phthalate exposure.Reproductive toxicology (Elmsford, N.Y.) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Ronit MachtingerDepartment of Obstetrics and Gynecology, Sheba Medical Center, Derech Sheba Ramat-Gan and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: Ronit.Machtinger@sheba.health.gov.il.
Tamar BermanPublic Health Services, Israel Ministry of Health, 39 Jeremiya Street, Jerusalem, Israel.
Michal AdirDepartment of Obstetrics and Gynecology, Sheba Medical Center, Derech Sheba Ramat-Gan and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Abdallah MansurDepartment of Obstetrics and Gynecology, Sheba Medical Center, Derech Sheba Ramat-Gan and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia University, Mailman School of Public Health, New York, NY, USA.
Catherine RacowskyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Antonia M CalafatNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Russ HauserDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ravit NahumDepartment of Obstetrics and Gynecology, Sheba Medical Center, Derech Sheba Ramat-Gan and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Sheba Medical Center · ILTel Aviv University · ILBrigham and Women's Hospital · USCenters for Disease Control and Prevention · USColumbia University · USHarvard University · USIsrael Ministry of Health · IL

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Environmental Chemicals, Exosomal miRNAs in Ovarian Follicles, and IVF SuccessR21ES024236 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B · 2014 to 2015
$470k
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R21 ES024236
6 · The paper itself

Abstract

Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives. We detected 14 of the 31 biomarkers in more than 90% of the women. We detected biomarkers of 1,2‑cyclohexane dicarboxylic acid, diisononyl ester (DINCH), bisphenol S, and bisphenol F not as frequently (27-56%). This study is the first to evaluate exposure to triclosan, bisphenols, parabens, and phthalates and BPA alternatives among Israeli pregnant women.

Indexed as

Benzhydryl CompoundsBiomarkersBisphenol A CompoundsCosmeticsDiethylhexyl PhthalateFemaleHumansIsraelMaternal ExposurePhenolsPregnancyBenzhydryl CompoundsBiomarkersbisphenol ABisphenol A CompoundsCosmeticsDiethylhexyl PhthalatePhenolsAlternativesBisphenolsPersonal care product chemicalsPhthalatesPregnancy

Identifiers

PMID29754027
PMCPMC5983044
OpenAlexW2802324651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.