ArticleJournal of affective disorders2018
Resilience and amygdala function in older healthy and depressed adults.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- The effect and neural changes underlying mindfulness meditation training in patients with comorbid internet gaming disorder and depression: A randomized clinical trial.Translational psychiatry · 2026Trial
- Hemispheric asymmetries and network dysfunctions in adolescent depression: A neuroimaging study using resting-state functional magnetic resonance imaging.World journal of psychiatry · 2025Trial
- Relationship between psychological resilience and cognitive function on breast cancer chemotherapy patients: a person-centered method.Breast cancer (Tokyo, Japan) · 2025Article
- Perceived Stress, Resilience and Emotional Intelligence in Romanian Healthcare Professionals.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.Brain and behavior · 2024Article
- Dietary omega-3 polyunsaturated fatty acids reduce cytochrome c oxidase in brain white matter and sensorimotor regions while increasing functional interactions between neural systems related to escape behavior in postpartum rats.Frontiers in systems neuroscience · 2024Article
- Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study.The journal of headache and pain · 2023Article
- Conceptualizing psychological resilience through resting-state functional MRI in a mentally healthy population: a systematic review.Frontiers in behavioral neuroscience · 2023Review
- Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic.Journal of affective disorders · 2022Article
- Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.Frontiers in psychiatry · 2022Article
- Sex-linked neurofunctional basis of psychological resilience in late adolescence: a resting-state functional magnetic resonance imaging study.European child & adolescent psychiatry · 2020Article
- Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Psychobiological factors of resilience and depression in late life.Translational psychiatry · 2019Review
- When the golden years turn blue.Nature medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies suggest that low emotional resilience may correspond with increased or over-active amygdala function. Complementary studies suggest that emotional resilience increases with age; older adults tend to have decreased attentional bias to negative stimuli compared to younger adults. Amygdala nuclei and related brain circuits have been linked to negative affect, and depressed patients have been demonstrated to have abnormal amygdala function.
methodsIn the current study, we correlated psychological resilience measures with amygdala function measured with resting-state arterial spin-labelled (ASL) and blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in older adults with and without depression. Specifically, we targeted the basolateral, centromedial, and superficial nuclei groups of the amygdala, which have different functions and brain connections.
resultsHigh levels of psychological resilience correlated with lower basal levels of amygdala activity measured with ASL fMRI. High resilience also correlated with decreased connectivity between amygdala nuclei and the ventral default-mode network independent of depression status. Instead, lower depression symptoms were associated with higher connectivity between the amygdalae and dorsal frontal networks. LIMITATIONS: Future multi-site studies with larger sample size and improved neuroimaging technologies are needed. Longitudinal studies that target resilience to naturalistic stressors will also be a powerful contribution to the field.
conclusionsOur results suggest that resilience in older adults is more closely related to function in ventral amygdala networks, while late-life depression is related to reduced connectivity between the amygdala and dorsal frontal regions.
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