Evidence map›Paper›PMID 29753780›Full record

ReviewJournal of molecular biology2018

The Role of RNA in Biological Phase Separations.

Marta M Fay, Paul J Anderson

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Review
  3. How do RNA molecules distinguish self from non-self?Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Aldolase-regulated G3BP1/2The EMBO journal · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Single-Molecular Dissection of Liquid-Liquid Phase Transitions.Journal of the American Chemical Society · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marta M FayDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Paul J AndersonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: panderson@rics.bwh.harvard.edu.
Harvard University · US

Funding

IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2M
CYTOLYTIC EFFECTOR MECHANISMS OF NUCLEOLYSIN TIA-1R01AI033600 · NIAID · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, PAUL J. · 1993 to 2010
$3.4M
Cellular Stress Response MechanismsR35GM126901 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2018 to 2022
$2.9M
Stress granules and cell signalingR01GM111700 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2014 to 2017
$1.3M
Angiogenin-Induced RNA Cleavage in CancerR01CA168872 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2013 to 2015
$1.1M
NCI NIH HHS R01 CA168872NIAID NIH HHS R01 AI033600NIAID NIH HHS T32 AI007306NIGMS NIH HHS R01 GM111700NIGMS NIH HHS R35 GM126901
6 · The paper itself

Abstract

Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the spacial and temporal organization of the densely packed intracellular environment. This allows cells to organize biologically coupled processes as well as respond to environmental stimuli. RNA plays a key role in phase separation events that modulate various aspects of RNA metabolism. Here, we review the role that RNA plays in ribonucleoprotein phase separations.

Indexed as

AnimalsCytoplasmHumansOrganellesPhase TransitionRibonucleoproteinsRNARibonucleoproteinsRNAmembraneless organellephase separationRNA

Identifiers

PMID29753780
PMCPMC6204303
OpenAlexW2800374982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.