ReviewNeuroscience and biobehavioral reviews2018
The cingulum bundle: Anatomy, function, and dysfunction.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 431 papers, 10 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
431 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- White matter abnormalities in tuberous sclerosis complex: a systematic review of diffusion tensor imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Pooled it
- Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.Brain imaging and behavior · 2025Pooled it
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- The role of the amygdala in depression: a bibliometric analysis (2015-2024).Frontiers in psychiatry · 2025Pooled it
- Effect of Levetiracetam on Cognition: A Systematic Review and Meta-analysis of Double-Blind Randomized Placebo-Controlled Trials.CNS drugs · 2024Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis.Brain imaging and behavior · 2023Pooled it
- Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review.Neurosurgical review · 2023Pooled it
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real-Time fMRI Neurofeedback.Depression and anxiety · 2025Trial
- Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI.Translational psychiatry · 2024Trial
- Substance use involvement moderates the effect of cortisol response on white-matter microstructure longitudinally.Dialogues in clinical neuroscience · 2026Article
- Dose-dependent power and connectivity modulation of low frequency oscillations through transcranial magnetic stimulation in non-human primates.Journal of neural engineering · 2026Article
- White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Unsupervised Clustering of ACC and Hippocampal Metabolites Identifies Subgroups in Antipsychotic-Naïve First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- A reproducible low-dimensional architecture of human white-matter connectivity.Research square · 2026Article
- The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.Brain imaging and behavior · 2026Article
- Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.CNS neuroscience & therapeutics · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
371 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum's composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle. Next, the impact of cingulum bundle damage in rats, monkeys, and humans is analysed. Despite causing extensive anatomical disconnections, cingulum bundle lesions typically produce only mild deficits, highlighting the importance of parallel pathways and the distributed nature of its various functions. Meanwhile, non-invasive imaging implicates the cingulum bundle in executive control, emotion, pain (dorsal cingulum), and episodic memory (parahippocampal cingulum), while clinical studies reveal cingulum abnormalities in numerous conditions, including schizophrenia, depression, post-traumatic stress disorder, obsessive compulsive disorder, autism spectrum disorder, Mild Cognitive Impairment, and Alzheimer's disease. Understanding the seemingly diverse contributions of the cingulum will require better ways of isolating pathways within this highly complex tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.