Evidence map›Paper›PMID 29753670›Full record

ArticleJournal of cardiothoracic and vascular anesthesia2018

Intraoperative Renal Resistive Index as an Acute Kidney Injury Biomarker: Development and Validation of an Automated Analysis Algorithm.

Benjamin Y Andrew, Elias Y Andrew, Anne D Cherry, Jennifer N Hauck, Alina Nicoara, Carl F Pieper, Mark Stafford-Smith

Abstract readValidation Study
In one paragraph

Article in Journal of cardiothoracic and vascular anesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin Y AndrewDepartment of Anesthesiology, Duke University Medical Center, Durham, NC; Clinical Research Training Program, Duke University School of Medicine, Durham, NC.
Elias Y AndrewDepartment of Electrical and Computer Engineering, School of Engineering and Applied Sciences, The George Washington University, Washington, DC.
Anne D CherryDepartment of Anesthesiology, Duke University Medical Center, Durham, NC.
Jennifer N HauckDepartment of Anesthesiology, Duke University Medical Center, Durham, NC.
Alina NicoaraDepartment of Anesthesiology, Duke University Medical Center, Durham, NC.
Carl F PieperDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC.
Mark Stafford-SmithDepartment of Anesthesiology, Duke University Medical Center, Durham, NC. Electronic address: mark.staffordsmit@dm.duke.edu.

Funding

INTEGRATED TRAINING IN ANESTHESIOLOGY RESEARCHT32GM008600 · NIGMS · DUKE UNIVERSITY · PI Miriam Treggiari · 1996 to 2026
$6.6M
Duke CTSA (Composite)TL1TR001116 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, KRAFT, MONICA · 2013 to 2017
$1.2M
NCATS NIH HHS TL1 TR001116NIGMS NIH HHS T32 GM008600
6 · The paper itself

Abstract

objectiveIntraoperative Doppler-determined renal resistive index (RRI) is a promising early acute kidney injury (AKI) biomarker. As RRI continues to be studied, its clinical usefulness and robustness in research settings will be linked to the ease, efficiency, and precision with which it can be interpreted. Therefore, the authors assessed the usefulness of computer vision technology as an approach to developing an automated RRI-estimating algorithm with equivalent reliability and reproducibility to human experts.

designRetrospective.

settingSingle-center, university hospital.

participantsAdult cardiac surgery patients from 7/1/2013 to 7/10/2014 with intraoperative transesophageal echocardiography-determined renal blood flow measurements.

interventionsNone. MEASUREMENTS AND MAIN

resultsRenal Doppler waveforms were obtained retrospectively and assessed by blinded human expert raters. Images (430) were divided evenly into development and validation cohorts. An algorithm for automated RRI analysis was built using computer vision techniques and tuned for alignment with experts using bootstrap resampling in the development cohort. This algorithm then was applied to the validation cohort for an unbiased assessment of agreement with human experts. Waveform analysis time per image averaged 0.144 seconds. Agreement was excellent by intraclass correlation coefficient (0.939; 95% confidence interval [CI] 0.921 to 0.953) and in Bland-Altman analysis (mean difference [human-algorithm] -0.0015; 95% CI -0.0054 to 0.0024), without evidence of systematic bias.

conclusionThe authors confirmed the value of computer vision technology to develop an algorithm for RRI estimation from automatically processed intraoperative renal Doppler waveforms. This simple-to-use and efficient tool further adds to the clinical and research value of RRI, already the "earliest" among several early AKI biomarkers being assessed.

Indexed as

Acute Kidney InjuryAgedAlgorithmsBiomarkersCardiac Surgical ProceduresCreatinineEchocardiography, TransesophagealFemaleFollow-Up StudiesHumansKidneyMaleMiddle AgedMonitoring, IntraoperativePostoperative ComplicationsPredictive Value of TestsBiomarkersCreatinineacute kidney injuryalgorithmscardiac surgerycomputer visionDoppler echocardiographyimage processing

Identifiers

PMID29753670
PMCPMC6153038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.