Sphingomyelin ability to act as chiral selector using nanodisc electrokinetic chromatography.

William M Penny, Christopher P Palmer

Abstract read

In one paragraph

Article in Chemistry and physics of lipids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes.Membranes · 2022
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William M PennyDepartment of Chemistry and Biochemistry, University of Montana, Missoula, MT 59803, United States.

Christopher P PalmerDepartment of Chemistry and Biochemistry, University of Montana, Missoula, MT 59803, United States. Electronic address: christopher.palmer@umontana.edu.

Funding

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP20GM103546 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2012 to 2021

$19.2M

NIGMS NIH HHS P20 GM103546

6 · The paper itself

Abstract

Understanding how stereochemistry affects interactions with cell membranes is important for effective drug development. Chirality has been shown to greatly effect pharmaceutical distribution and metabolism within the cell. However it has been thought that interactions with, and passive diffusion through, the membrane are not stereochemically selective. Various studies have produced conflicting results regarding whether interactions with lipid bilayers are or can be stereoselective. In the current work, stereoselective interactions between a pair of atropisomers, R-(+)/(S)-(-) 1,1'-Bi-2-naphthol, and sphingomyelin nanodisc bilayers, are demonstrated. This is accomplished using nanodisc electrokinetic chromatography, demonstrating that this approach is sensitive to subtle differences in affinity between small molecule probes and lipid bilayers. Using the same approach, no evidence of stereoselectivity was observed using enantiomer or diastereomer probes of varied chemistry and structure.

Indexed as

Chromatography, Micellar Electrokinetic CapillaryLipid BilayersNanostructuresNaphtholsSphingomyelinsStereoisomerism2-naphtholLipid BilayersNaphtholsSphingomyelinsAtropisomerCapillary electrophoresisLipid bilayerStereoselectivity

Identifiers

PMID29753650

DOI10.1016/j.chemphyslip.2018.05.002

PMCPMC6657505

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