ArticleAtherosclerosis2018
Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.
Article in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Trial
- Article
- Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Y-Chromosome Gene,American journal of respiratory and critical care medicine · 2022Article
- Observational
- Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence.Human reproduction (Oxford, England) · 2020Article
- Review
- Age at period cessation and trajectories of cardiovascular risk factors across mid and later life.Heart (British Cardiac Society) · 2020Article
- Preliminary study between Y chromosome haplogroups and chagasic cardiomyopathy manifestations in patients with Chagas disease.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study.Clinical epigenetics · 2019Article
- Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC).Data in brief · 2019Article
- Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children.Wellcome open research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
aimsMales have greater cardiometabolic risk than females, though the reasons for this are poorly understood. The aim of this study was to examine the association between common Y chromosomal haplogroups and cardiometabolic risk during early life.
methodsIn a British birth cohort, we examined the association of Y chromosomal haplogroups with trajectories of cardiometabolic risk factors from birth to 18 years and with carotid-femoral pulse wave velocity, carotid intima media thickness and left ventricular mass index at age 18. Haplogroups were grouped according to their phylogenetic relatedness into categories of R, I, E, J, G and all other haplogroups combined (T, Q, H, L, C, N and O). Risk factors included BMI, fat and lean mass, systolic blood pressure (SBP), diastolic blood pressure, pulse rate, triglycerides, high density lipoprotein cholesterol (HDL-c), non-HDL-c and c-reactive protein. Analyses were performed using multilevel models and linear regression, as appropriate.
resultsY chromosomal haplogroups were not associated with any cardiometabolic risk factors from birth to 18 years. For example, at age 18, the difference in SBP comparing each haplogroup with haplogroup R was -0.39 mmHg (95% Confidence Interval (CI): -0.75, 1.54) for haplogroup I, 2.56 mmHg (95% CI: -0.76, 5.89) for haplogroup E, -0.02 mmHg (95% CI: -2.87, 2.83) for haplogroup J, 1.28 mmHg (95% CI: -4.70, 2.13) for haplogroup G and -2.75 mmHg (95% CI: -6.38, 0.88) for all other haplogroups combined.
conclusionsCommon Y chromosomal haplogroups are not associated with cardiometabolic risk factors during childhood and adolescence or with subclinical cardiovascular measures at age 18.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.