Evidence map›Paper›PMID 29753119›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2018

Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection.

Wan Beom Park, Leo L M Poon, Su-Jin Choi, Pyoeng Gyun Choe, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Distinct Molecular Mechanisms Characterizing Pathogenesis of SARS-CoV-2.Journal of microbiology and biotechnology · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wan Beom ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea.
Leo L M PoonSchool of Public Health, The University of Hong Kong, Pokfulam, Hong Kong, China.
Su-Jin ChoiLaboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea.
Pyoeng Gyun ChoeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Kyoung-Ho SongDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Ji Hwan BangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Eu Suk KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Hong Bin KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Sang Won ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Nam Joong KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea.
Malik PeirisSchool of Public Health, The University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address: malik@hku.hk.
Myoung-Don OhDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea. Electronic address: mdohmd@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInformation on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens.

methodsUpper and lower respiratory samples were obtained from 17 MERS-CoV-infected patients. MERS-CoV sub-genomic mRNA was detected by reverse transcription PCR (RT-PCR) and MERS-CoV genomic RNA by real-time RT-PCR.

resultsIn sputum and transtracheal aspirate, sub-genomic mRNA was detected for up to 4 weeks after symptoms developed, which correlated with the detection of genomic RNA. In oropharyngeal and nasopharyngeal swab specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate.

conclusionsThese findings suggest that MERS-CoV does not replicate well in the upper respiratory tract.

Indexed as

Virus ReplicationVirus SheddingCoronavirus InfectionsHumansMiddle East Respiratory Syndrome CoronavirusReal-Time Polymerase Chain ReactionRespiratory SystemReverse TranscriptionSputumCoronavirus infectionsMessengerRespiratory systemRNA

Identifiers

PMID29753119
PMCPMC7110884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.