Evidence map›Paper›PMID 29753105›Full record

ArticleNeuroImage2018

Cortical fibers orientation mapping using in-vivo whole brain 7 T diffusion MRI.

Omer F Gulban, Federico De Martino, An T Vu, Essa Yacoub, Kamil Uğurbil, Christophe Lenglet

Open access · greenAbstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  15. Diffusion Imaging in the Post HCP Era.Journal of magnetic resonance imaging : JMRI · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Omer F GulbanDepartment of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands.
Federico De MartinoDepartment of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands.
An T VuVeterans Affairs Health Care System, San Francisco, CA, USA.
Essa YacoubCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Kamil UğurbilCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Christophe LengletCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA. Electronic address: clenglet@umn.edu.
Resonance Research (United States) · USMaastricht University · NLSan Francisco VA Health Care System · US

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Elementary Neuronal Ensembles to Whole Brain Networks: Ultrahigh Resolution Imaging of Function and Connectivity in Humans - SUPPLEMENTU01EB025144 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2017 to 2022
$9.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
NIBIB NIH HHS P41 EB015894NIBIB NIH HHS U01 EB025144NIMH NIH HHS U54 MH091657NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

Diffusion MRI of the cortical gray matter is challenging because the micro-environment probed by water molecules is much more complex than within the white matter. High spatial and angular resolutions are therefore necessary to uncover anisotropic diffusion patterns and laminar structures, which provide complementary (e.g. to anatomical and functional MRI) microstructural information about the cortex architectonic. Several ex-vivo and in-vivo MRI studies have recently addressed this question, however predominantly with an emphasis on specific cortical areas. There is currently no whole brain in-vivo data leveraging multi-shell diffusion MRI acquisition at high spatial resolution, and depth dependent analysis, to characterize the complex organization of cortical fibers. Here, we present unique in-vivo human 7T diffusion MRI data, and a dedicated cortical depth dependent analysis pipeline. We leverage the high spatial (1.05 mm isotropic) and angular (198 diffusion gradient directions) resolution of this whole brain dataset to improve cortical fiber orientations mapping, and study neurites (axons and/or dendrites) trajectories across cortical depths. Tangential fibers in superficial cortical depths and crossing fiber configurations in deep cortical depths are identified. Fibers gradually inserting into the gyral walls are visualized, which contributes to mitigating the gyral bias effect. Quantitative radiality maps and histograms in individual subjects and cortex-based aligned datasets further support our results.

Indexed as

Nerve FibersAdultAxonsCerebral CortexDendritesDiffusion Magnetic Resonance ImagingHumansImage Processing, Computer-AssistedNeuritesNeuroimaging7 TCortexDepth dependent analysisDiffusion MRIGyral biasHigh resolution

Identifiers

PMID29753105
PMCPMC6118131
OpenAlexW2801602622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.