Evidence map›Paper›PMID 29752967›Full record

ArticleJournal of molecular biology2018

HIV-1 Matrix Protein Interactions with tRNA: Implications for Membrane Targeting.

Christy R Gaines, Emre Tkacik, Amalia Rivera-Oven, Phoebe Somani, Alecia Achimovich, Tawakalitou Alabi, Angela Zhu, Noel Getachew, Ae Lim Yang, Matthew McDonough and 3 more

Abstract read
In one paragraph

Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  2. Review
  3. Review
  4. The "basics" of HIV-1 assembly.PLoS pathogens · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Christy R GainesHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Emre TkacikHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Amalia Rivera-OvenHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Phoebe SomaniHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Alecia AchimovichHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Tawakalitou AlabiHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Angela ZhuHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Noel GetachewHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Ae Lim YangHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Matthew McDonoughHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Tarik HawkinsHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Zoe SpadaroHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Michael F SummersHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. Electronic address: summers@hhmi.umbc.edu.
University of Maryland, Baltimore County · USHoward Hughes Medical Institute · US

Funding

The MARC U*STAR Program at UMBCT34GM008663 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI ROBINSON, PHYLLIS R · 1997 to 2019
$21.9M
EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
The Center for HIV RNA Studies (CRNA)U54GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2017 to 2018
$10.2M
NMR STUDIES OF RETROVIRAL NUCLEOCAPSID PROTEINSR01GM042561 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1994 to 2019
$9.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM042561NIGMS NIH HHS R25 GM055036NIGMS NIH HHS T34 GM008663NIGMS NIH HHS U54 GM103297
6 · The paper itself

Abstract

The N-terminally myristoylated matrix (MA) domain of the HIV-1 Gag polyprotein promotes virus assembly by targeting Gag to the inner leaflet of the plasma membrane. Recent studies indicate that, prior to membrane binding, MA associates with cytoplasmic tRNAs (including tRNA

Indexed as

CalorimetryCell MembraneCytoplasmgag Gene Products, Human Immunodeficiency VirusHIV-1HumansMagnetic Resonance SpectroscopyModels, MolecularMutationMyristic AcidPhosphatidylinositol 4,5-DiphosphateProtein DomainsRNA, TransferVirus Assemblygag Gene Products, Human Immunodeficiency VirusMyristic AcidPhosphatidylinositol 4,5-DiphosphateRNA, TransferHIVliposomesmatrix proteinmembranetRNA

Identifiers

PMID29752967
PMCPMC6051522
OpenAlexW2800041319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.