Evidence map›Paper›PMID 29752830›Full record

ArticleJournal of personality2019

Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism.

Abdel Abdellaoui, Hsi-Yuan Chen, Gonneke Willemsen, Erik A Ehli, Gareth E Davies, Karin J H Verweij, Michel G Nivard, Eco J C de Geus, Dorret I Boomsma, John T Cacioppo

Abstract readTwin Study
In one paragraph

Article in Journal of personality, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The Stability and Change of Loneliness Across the Life Span: A Meta-Analysis of Longitudinal Studies.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2020
    Pooled it
  4. Article
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  8. Multidimensional Loneliness Among University Students: A Latent Profile Approach.International journal of environmental research and public health · 2025
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdel AbdellaouiDepartment of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-1088-6784
Hsi-Yuan ChenDepartment of Psychology, University of Chicago, Chicago, Illinois, USA.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Erik A EhliAvera Institute for Human Genetics, Sioux Falls, South Dakota, USA.
Gareth E DaviesAvera Institute for Human Genetics, Sioux Falls, South Dakota, USA.
Karin J H VerweijDepartment of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Michel G NivardDepartment of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
John T CacioppoDepartment of Psychology, University of Chicago, Chicago, Illinois, USA.

Funding

Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Social Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5M
Social Regulation of Gene ExpressionR01AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, STEPHANIE · 2018 to 2019
$720k
EPA EP-C-15-001NIA NIH HHS R01 AG033590NIA NIH HHS R37 AG033590NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995
6 · The paper itself

Abstract

objectiveLoneliness is an aversive response to a discrepancy between desired and actual social relationships and correlates with personality. We investigate the relationship of loneliness and personality in twin family and molecular genetic data.

methodPhenotypic correlations between loneliness and the Big Five personality traits were estimated in 29,625 adults, and in a group with genome-wide genotype data (N = 4,222), genetic correlations were obtained. We explored whether genetic correlations may reflect causal relationships by investigating within monozygotic twin pair differences (N

resultsThe strongest correlations with loneliness were observed for Neuroticism (r = .55) and Extraversion (r = -.33). Only Neuroticism showed a high correlation with loneliness independent of other personality traits (r = .50), so follow-up analyses focused on Neuroticism. The genetic correlation between loneliness and Neuroticism from genotyped variants was .71; a significant reciprocal causal relationship and nonsignificant cross-trait assortative mating imply that this is at least partly due to mediated pleiotropy.

conclusionsWe show that the relationship between loneliness and personality is largely explained by its relationship with Neuroticism, which is substantially genetic in nature.

Indexed as

LonelinessRegistriesAdolescentAdultAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedNetherlandsNeuroticismPersonalityPhenotypePolymorphism, Single Nucleotide

Identifiers

PMID29752830
PMCPMC6231981

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.