Evidence map›Paper›PMID 29752801›Full record

ArticleJournal of biomedical optics2018

In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation.

Yiming Lu, Changgeng Liu, Xincheng Yao

Open access · goldAbstract readLetter
In one paragraph

Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Functional optical coherence tomography enablesBiomedical optics express · 2020
    Article
  5. Review
  6. Functional optical coherence tomography of retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2018
    Review
  7. Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments.Translational vision science & technology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yiming LuUniversity of Illinois at Chicago, Department of Bioengineering, Chicago, Illinois, United States.
Changgeng LiuUniversity of Illinois at Chicago, Department of Bioengineering, Chicago, Illinois, United States.
Xincheng YaoUniversity of Illinois at Chicago, Department of Bioengineering, Chicago, Illinois, United States.
University of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Functional imaging of retinal photoreceptorsR01EY023522 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2014 to 2024
$3.5M
Super-resolution ophthalmoscopy for in vivo retinal imagingR01EY024628 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2014 to 2016
$1.1M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY023522NEI NIH HHS R01 EY024628
6 · The paper itself

Abstract

Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction.

Indexed as

RetinaAnimalsMicroscopyOphthalmoscopyPhotic StimulationPhototropismRana pipiensfunctional imagingophthalmoscopyphotoreceptorretinasuper-resolution microscopy

Identifiers

PMID29752801
PMCPMC5946809
OpenAlexW2799604205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.