ArticleJournal of cellular and molecular medicine2018
Mesenchymal stem cells promote lymphangiogenic properties of lymphatic endothelial cells.
Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Interventions and platforms that direct lymphangiogenesis to restore physiological homeostasis and enhance immunoregulation.NPJ Regenerative medicine · 2026Review
- Cutaneous lymphatics and skin diseases: mechanisms, imaging modalities, and future therapeutic strategies.Frontiers in physiology · 2026Review
- Mechanobiological modulation: physiological pressure preconditioning boosts the paracrine-driven lymphangiogenic capacity of bone marrow mesenchymal stem cells.Frontiers in physiology · 2026Article
- IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.Frontiers in genetics · 2025Article
- Engineering ADSCs by manipulating YAP for lymphedema treatment in a mouse tail model.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Lymphangiogenesis: novel strategies to promote cutaneous wound healing.Burns & trauma · 2024Review
- Synthetic hyaluronic acid coating preserves the phenotypes of lymphatic endothelial cells.Biomaterials science · 2023Article
- Fibroblast-Generated Extracellular Matrix Guides Anastomosis during Wound Healing in an Engineered Lymphatic Skin Flap.Bioengineering (Basel, Switzerland) · 2023Article
- Networked lymphatic endothelial cells in a transplanted cell sheet contribute to form functional lymphatic vessels.Scientific reports · 2022Article
- Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.Cancer medicine · 2022Article
- Osteopathy in Complex Lymphatic Anomalies.International journal of molecular sciences · 2022Review
- A Challenge for Engineering Biomimetic Microvascular Models: How do we Incorporate the Physiology?Frontiers in bioengineering and biotechnology · 2022Review
- Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration.Journal of translational medicine · 2021Review
- Engineering the Lymphatic Network: A Solution to Lymphedema.Advanced healthcare materials · 2021Review
- Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells.Heliyon · 2020Article
- Size matters-in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes.Journal of materials science. Materials in medicine · 2020Article
- The Microvascular Peroneal Artery Perforator Flap as a "Lifeboat" for Pedicled Flaps.Plastic and reconstructive surgery. Global open · 2019Article
- The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment.Frontiers in immunology · 2019Review
- Review
- Mesenchymal stem cells promote lymphangiogenic properties of lymphatic endothelial cells.Journal of cellular and molecular medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Lymphatic metastasis is one of the main prognostic factors concerning long-term survival of cancer patients. In this regard, the molecular mechanisms of lymphangiogenesis are still rarely explored. Also, the interactions between stem cells and lymphatic endothelial cells (LEC) in humans have not been well examined. Therefore, the main objective of this study was to assess the interactions between mesenchymal stem cells (MSC) and LEC using in vitro angiogenesis assays. Juvenile LEC were stimulated with VEGF-C, bFGF, MSC-conditioned medium (MSC-CM) or by co-culture with MSC. LEC proliferation was assessed using a MTT assay. Migration of the cells was determined with a wound healing assay and a transmigration assay. To measure the formation of lymphatic sprouts, LEC spheroids were embedded in collagen or fibrin gels. The LEC's capacity to form capillary-like structures was assessed by a tube formation assay on Matrigel
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.