Evidence map›Paper›PMID 29752748›Full record

ArticleAmerican journal of human biology : the official journal of the Human Biology Council2018

Epstein-Barr virus antibody titer as a stress biomarker and its association with social capital in rural Fujian communities, China.

Aki Yazawa, Yosuke Inoue, Guoxi Cai, Raoping Tu, Meng Huang, Fei He, Jie Chen, Taro Yamamoto, Chiho Watanabe

Open access · greenAbstract read
In one paragraph

Article in American journal of human biology : the official journal of the Human Biology Council, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Circulating Epstein-Barr Virus Antibody Levels as a Biomarker of Socioecological Adversity in Amazonian Ecuador.American journal of human biology : the official journal of the Human Biology Council · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Aki YazawaDepartment of Human Ecology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0002-4335-3880
Yosuke InoueDepartment of Human Ecology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Guoxi CaiNagasaki Prefectural Institute of Environment and Public Health, Omura-shi, Nagasaki, 856-0026, Japan.
Raoping TuDepartment of International Health, Institute of Tropical Medicine (NEKKEN), Nagasaki-shi, Nagasaki University, Nagasaki, 852-8523, Japan.
Meng HuangFujian Provincial Center for Disease Control and Prevention, Fuzhou, Fujian, 350001, China.
Fei HeDepartment of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Jie ChenDepartment of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Taro YamamotoDepartment of International Health, Institute of Tropical Medicine (NEKKEN), Nagasaki-shi, Nagasaki University, Nagasaki, 852-8523, Japan.
Chiho WatanabeDepartment of Human Ecology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Bunkyo University · JPFujian Medical University · CNNagasaki International University · JPEducation Department of Fujian Province · CNNagasaki Institute of Applied Science · JPUniversity of North Carolina at Chapel Hill · US

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
NICHD NIH HHS P2C HD050924
6 · The paper itself

Abstract

objectivesThere has been little research on the association between social capital and psychological stress measured by a biomarker, particularly in developing countries. Our objective was to investigate the association between Epstein-Barr virus (EBV) antibody titer, an indicator of cellular immune function previously shown to be associated with psychological stress, and social capital among rural community dwellers in Fujian Province, China.

methodsWe conducted a cross-sectional survey in seven rural communities in Fujian in 2015. We used questionnaire data and dried blood spot samples for the measurement of biomarkers collected from 734 local residents for the analysis. We conducted a mixed effects regression analysis to investigate the association between EBV antibody titer and four social capital variables, which included cognitive and structural social capital assessed both at individual and community levels.

resultsCommunity-level structural social capital was inversely associated with psychological stress (coefficient = -0.96, 95% confidence interval [CI] = -1.91, -0.01) while individual-level structural social capital was positively associated with it (coefficient = 0.21, 95% CI = 0.07, 0.36). Neither individual- nor community-level cognitive social capital was associated with psychological stress status.

conclusionsIn rural Fujian, China, social capital seemed to be an important determinant of psychological health. While living in a community with active social interaction may benefit the residents psychologically, social interaction in the form of strongly bonded relationships may be a source of psychological stress at the individual level due to the potential demands and obligations that may be associated with such connections.

Indexed as

Social CapitalAdultAgedAntibodies, ViralBiomarkersChinaCross-Sectional StudiesFemaleHerpesvirus 4, HumanHumansMaleMiddle AgedRural PopulationStress, PsychologicalAntibodies, ViralBiomarkers

Identifiers

PMID29752748
PMCPMC6687072
OpenAlexW2802514298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.