ArticleMagnetic resonance in medicine2018
J-difference-edited MRS measures of γ-aminobutyric acid before and after acute caffeine administration.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- GABA quantification in human anterior cingulate cortex.PloS one · 2021Trial
- Alteration of intracerebral metabolites and subjective sleepiness by acute caffeine administration in adults.Quantitative imaging in medicine and surgery · 2023Article
- A comprehensive guide to MEGA-PRESS for GABA measurement.Analytical biochemistry · 2023Review
- Increased GABA+ in People With Migraine, Headache, and Pain Conditions- A Potential Marker of Pain.The journal of pain · 2021Article
- In silico GABA+ MEGA-PRESS: Effects of signal-to-noise ratio and linewidth on modeling the 3 ppm GABA+ resonance.NMR in biomedicine · 2021Article
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Authors and funding
6 authors.
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Abstract
purposeThe aim of this study was to investigate potential effects of acute caffeine intake on J-difference-edited MRS measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA).
methodsJ-difference-edited Mescher-Garwood PRESS (MEGA-PRESS) and conventional PRESS data were acquired at 3T from voxels in the anterior cingulate and occipital area of the brain in 15 healthy subjects, before and after oral intake of a 200-mg caffeine dose. MEGA-PRESS data were analyzed with the MATLAB-based Gannet tool to estimate GABA+ macromolecule (GABA+) levels, while PRESS data were analyzed with LCModel to estimate levels of glutamate, glutamate+glutamine, N-acetylaspartate, and myo-inositol. All metabolites were quantified with respect to the internal reference compounds creatine and tissue water, and compared between the pre- and post-caffeine intake condition.
resultsFor both MRS voxels, mean GABA+ estimates did not differ before and after caffeine intake. Slightly lower estimates of myo-inositol were observed after caffeine intake in both voxels. N-acetylaspartate, glutamate, and glutamate+glutamine did not show significant differences between conditions.
conclusionMean GABA+ estimates from J-difference-edited MRS in two different brain regions are not altered by acute oral administration of caffeine. These findings may increase subject recruitment efficiency for MRS studies.
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