ArticleAnnals of neurology2018
Filter-probe diffusion imaging improves spinal cord injury outcome prediction.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Detecting and characterizing restricted diffusion with accessible magnetic field gradients.PNAS nexus · 2026Article
- Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord.Magnetic resonance imaging · 2024Article
- Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.Annals of clinical and translational neurology · 2023Article
- The Role of Magnetic Resonance Imaging and Computed Tomography in Spinal Cord Injury.Life (Basel, Switzerland) · 2023Review
- Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain communications · 2023Article
- Diffusion-weighted MRI of the spinal cord in cervical spondylotic myelopathy after instrumented fusion.Frontiers in neurology · 2023Article
- Acute Magnetic Resonance Imaging Predictors of Chronic Motor Function and Tissue Sparing in Rat Cervical Spinal Cord Injury.Journal of neurotrauma · 2022Article
- Diffusion MR imaging acquisition and analytics for microstructural delineation in pre-clinical models of TBI.Journal of neuroscience research · 2022Review
- Diffusion-prepared fast spin echo for artifact-free spinal cord imaging.Magnetic resonance in medicine · 2021Article
- Optimized cervical spinal cord perfusion MRI after traumatic injury in the rat.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging.NeuroImage · 2020Article
- Multispectral diffusion-weighted MRI of the instrumented cervical spinal cord: a preliminary study of 5 cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Article
- Evolution of Magnetic Resonance Imaging as Predictors and Correlates of Functional Outcome after Spinal Cord Contusion Injury in the Rat.Journal of neurotrauma · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveDiffusion-weighted imaging (DWI) is a powerful tool for investigating spinal cord injury (SCI), but has limited specificity for axonal damage, which is the most predictive feature of long-term functional outcome. In this study, a technique designed to detect acute axonal injury, filter-probe double diffusion encoding (FP-DDE), is compared with standard DWI for predicting long-term functional and cellular outcomes.
methodsThis study extends FP-DDE to predict long-term functional and histological outcomes in a rat SCI model of varying severities (n = 58). Using a 9.4T magnetic resonance imaging (MRI) system, a whole-cord FP-DDE spectroscopic voxel was acquired in 3 minutes at the lesion site and compared to DWI at 48 hours postinjury. Relationships with chronic (30-day) locomotor and histological outcomes were evaluated with linear regression.
resultsThe FP-DDE measure of parallel diffusivity (ADC
interpretationCollectively, these results demonstrate FP-DDE benefits from greater specificity for acute axonal damage in predicting functional and histological outcomes with rapid acquisition and fully automated analysis, improving over standard DWI. FP-DDE is a promising technique compatible with clinical settings, with potential research and clinical applications for evaluation of spinal cord pathology. Ann Neurol 2018;83:37-50.
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