ArticleBrain imaging and behavior2019
Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Using fMRI to Assess Brain Activity in People With Down Syndrome: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- Beyond CT: Attenuation correction for stand-alone brain PET.Zeitschrift fur medizinische Physik · 2026Review
- Distinct brain regions are affected by neurodevelopmental or pre-dementia changes in Down syndrome.Brain communications · 2026Article
- Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Resistance and resilience to Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Measurement of synaptic density in Down syndrome using PET imaging: a pilot study.Scientific reports · 2024Article
- AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Weight Loss and Alzheimer's Disease in Down Syndrome.Journal of Alzheimer's disease : JAD · 2023Article
- Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome.Neurobiology of aging · 2022Article
- Unified spatial normalization method of brain PET images using adaptive probabilistic brain atlas.European journal of nuclear medicine and molecular imaging · 2022Article
- Joint-label fusion brain atlases for dementia research in Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome.Journal of Alzheimer's disease : JAD · 2022Article
- Article
- The promotion of physical activity for the prevention of Alzheimer's disease in adults with Down Syndrome: Rationale and design for a 12 Month randomized trial.Contemporary clinical trials communications · 2020Article
- Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome.Neurobiology of aging · 2020Article
- Amyloid accumulation in Down syndrome measured with amyloid load.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and the use of normative atlases developed for the non-DS population. Further, the use of typical MRI to MRI template spatial normalization is less desirable in this cohort due to a greater presence of motion artefacts in MRI images. The diffuse nature of PiB uptake and comparatively lower spatial resolution of the PET image permits the purposing of this modality as a template for spatial normalization, which can substantially improve the robustness of this procedure in the cases of MRI images with motion. The aim of this work was to establish standardized methods for spatial normalization and tissue type segmentation using DS specific templates in order to perform voxel-wise analyses. A total of 72 adults with DS underwent [
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.