Evidence map›Paper›PMID 29752624›Full record

ReviewNeurochemical research2019

Gβγ SNARE Interactions and Their Behavioral Effects.

Simon Alford, Heidi Hamm, Shelagh Rodriguez, Zack Zurawski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. StandardizedAntioxidants (Basel, Switzerland) · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Simon AlfordDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, 60612-7308, USA. sta@uic.edu.ORCID http://orcid.org/0000-0002-0454-4246
Heidi HammDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37232-6600, USA.
Shelagh RodriguezDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, 60612-7308, USA.
Zack ZurawskiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, 60612-7308, USA.
University of Illinois Chicago · USVanderbilt University Medical Center · US

Funding

Synaptic Plasticity and the Dynamic Interactions Between Calcium and PresynapticR01MH084874 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALFORD, SIMON T · 2010 to 2014
$1.9M
GPCR Regulation of insulin secretion by modulation of the release machineryR01DK109204 · NIDDK · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 2016 to 2019
$1.4M
Optimization of modulators of Gbg-SNARE interactionR01MH101679 · NIMH · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, STAUFFER, SHAUN R · 2014 to 2016
$1.2M
National Institute of Mental Health RO1MH084874National Institutes of Health R01MH101679NIDDK NIH HHS R01 DK109204NIMH NIH HHS R01 MH084874NIMH NIH HHS R01 MH101679
6 · The paper itself

Abstract

Presynaptic terminals possess interlocking molecular mechanisms that control exocytosis. An example of such complexity is the modulation of release by presynaptic G Protein Coupled Receptors (GPCRs). GPCR ubiquity at synapses-GPCRs are present at every studied presynaptic terminal-underlies their critical importance in synaptic function. GPCRs mediate presynaptic modulation by mechanisms including via classical Gα effectors, but membrane-delimited actions of Gβγ can also alter probability of release by altering presynaptic ionic conductances. This directly or indirectly modifies action potential-evoked presynaptic Ca

Indexed as

Action PotentialsAnimalsCalciumExocytosisHumansPresynaptic TerminalsSNARE ProteinsSynaptic TransmissionCalciumSNARE ProteinsG proteinsLocomotionPresynapticPresynaptic inhibitionSerotoninShort term plasticity

Identifiers

PMID29752624
PMCPMC6230518
OpenAlexW2802193004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.