Evidence map›Paper›PMID 29752611›Full record

Trial reportChinese journal of integrative medicine2018

Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial.

Ji-Meng Zhao, Jin-Hua Lu, Xiao-Jun Yin, Lu-Yi Wu, Chun-Hui Bao, Xing-Kui Chen, Yue-Hua Chen, Wei-Jun Tang, Xiao-Ming Jin, Huan-Gan Wu and 1 more

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Chinese journal of integrative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  15. Integrative Approaches to Managing Gut Health.Current gastroenterology reports · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ji-Meng ZhaoShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Jin-Hua LuMedical Imaging Department, Jinhua Municipal Central Hospital, Jinhua, 321000, Zhejiang Province, China.
Xiao-Jun YinShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Lu-Yi WuShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Chun-Hui BaoShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Xing-Kui ChenDepartment of Acupuncture and Moxibustion, Jinhua Municipal Central Hospital, Jinhua, 321000, Zhejiang Province, China.
Yue-Hua ChenDepartment of Digestive System, Jinhua Municipal Central Hospital, Jinhua, 321000, Zhejiang Province, China.
Wei-Jun TangRadiology Department, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiao-Ming JinDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA.
Huan-Gan WuShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Yin ShiShanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China. flysy0636@163.com.
Shanghai University of Traditional Chinese Medicine · CNJinhua Central Hospital · CNFudan University · CNIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effects of electroacupuncture (EA) and mild-warm moxibustion (Mox) therapies for constipation-predominant irritable bowel syndrome (C-IBS) patients.

methodsSixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group (30 cases) and Mox group (30 cases). Both EA and Mox treatments were performed on bilateral Tianshu (ST 25) and Shangjuxu (ST 37) for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex (ACC), insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging (fMRI) before and after treatment.

resultsCompared with the Mox group, greater improvements in abdominal distension, defecation frequency, diffificulty in defecation and stool features were observed in the EA group (all P<0.01), both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were signifificantly decreased in the EA group (all P<0.01). Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation (P<0.05 or P<0.01).

conclusionsBoth EA and Mox could signifificantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. (Registration No. ChiCTRTRC-11001349).

Indexed as

ElectroacupunctureMoxibustionAdultBrainConstipationHumansIrritable Bowel SyndromeMagnetic Resonance ImagingPain MeasurementRectumSensory Thresholdsconstipationelectroacupunctureirritable bowel syndromemoxibustionrandomized controlled trial

Identifiers

PMID29752611
OpenAlexW2800831188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.