Evidence map›Paper›PMID 29752513›Full record

ReviewWorld journal of urology2019

Oligorecurrent prostate cancer limited to lymph nodes: getting our ducks in a row : Nodal oligorecurrent prostate cancer.

Andrei Fodor, Andrea Lancia, Francesco Ceci, Maria Picchio, Morten Hoyer, Barbara Alicja Jereczek-Fossa, Piet Ost, Paolo Castellucci, Elena Incerti, Nadia Di Muzio and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Stereotactic radiotherapy for bone oligometastases.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  8. Moderate hypofractionated post-prostatectomy radiation therapy is feasible and well tolerated: experience from a single tertiary cancer centre.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
  9. Article
  10. Salvage radiotherapy in patients affected by oligorecurrent pelvic nodal prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Article
  11. Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a multi-institutional analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrei FodorDepartment of Radiation Oncology, San Raffaele Scientific Institute, Milan, Italy.
Andrea LanciaDepartment of Radiotherapy, Tor Vergata General Hospital, Viale Oxford 81, 00133, Rome, Italy. andrea.lancia.dr@gmail.com.ORCID http://orcid.org/0000-0001-6106-7725
Francesco CeciDepartment of Molecular and Medical Pharmacology, Ahmanson Translational Imaging Division, University of California at Los Angeles (UCLA), Los Angeles, USA.
Maria PicchioUnit of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
Morten HoyerDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Barbara Alicja Jereczek-FossaDepartment of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Piet OstDepartment of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
Paolo CastellucciNuclear Medicine Unit, University of Bologna, S. Orsola Hospital Bologna, Bologna, Italy.
Elena IncertiUnit of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
Nadia Di MuzioDepartment of Radiation Oncology, San Raffaele Scientific Institute, Milan, Italy.
Gianluca IngrossoDepartment of Radiotherapy, Tor Vergata General Hospital, Viale Oxford 81, 00133, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOligorecurrent prostate cancer with exclusive nodal involvement represents a common state of disease, amenable to local therapy. New radio-labeled tracers have enriched the possibility of cancer detection and treatment. In this review, we aim to illustrate the main nuclear medicine diagnostic options and the role of radiotherapy in this setting of patients.

methodsWe performed a PubMed search referring to the PRISMA guidelines to analyze the performance of PSMA- and choline-PET in detecting oligorecurrence limited to lymph nodes, and to review the main studies supporting either ablative stereotactic body radiotherapy or regional lymph node irradiation in this clinical setting.

resultsPSMA-PET has shown higher efficacy in the diagnosis of nodal lesions if compared with choline-PET. More specifically, for PSA ≤ 2 ng/ml, the median detection rate of choline-PET ranges from 19.5 to 44.5%, whereas PSMA ranges from 51.5 to 74%. SBRT achieves high local control rates positively affecting progression-free survival (PFS), with androgen deprivation therapy (ADT)-free survival ranging from 25 to 44 months and with low toxicity rates (0-15%). Prophylactic nodal irradiation shows 3-year PFS rates ranging from 62 to 75%, but with a potential higher risk of toxicity. However, the chosen treatment option needs to be tailored on the single patient.

conclusionsNewer PET/CT radio-labeled tracers have increased disease detection in oligorecurrent prostate cancer patients. Growing evidence of their impact on metastasis-directed therapy encourages the use of the most advanced radiotherapy techniques in the clinical management of such patients.

Indexed as

CholineFluorine RadioisotopesGallium IsotopesGallium RadioisotopesHumansLymphatic MetastasisMaleMembrane GlycoproteinsNeoplasm Recurrence, LocalOrganometallic CompoundsPositron-Emission TomographyPractice Guidelines as TopicProstatic NeoplasmsCholineFluorine Radioisotopesfluorocholinegallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesMembrane GlycoproteinsOrganometallic CompoundsCholineOligorecurrentProstate cancerPSMARadiotherapySBRT

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.