ReviewNature reviews. Rheumatology2018
The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA.
Review in Nature reviews. Rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Serum levels of MMP3 could be used as a potential biomarker for sports-induced knee osteoarthritis.Journal of medical biochemistry · 2026Article
- Integration of gold standard arthroscopy, MRI and synovial histopathology outcomes for enhancing early knee osteoarthritis diagnosis.Aging clinical and experimental research · 2026Article
- MRI versus radiography as eligibility screening tool for knee osteoarthritis clinical trials: Data from the osteoarthritis initiative.Seminars in arthritis and rheumatism · 2025Article
- Early diagnosis of knee osteoarthritis severity using vision transformer.BMC musculoskeletal disorders · 2025Article
- miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.Cartilage · 2025Article
- Contralateral knee osteoarthritis severity relates to magnetic resonance imaging findings in knees with and without osteoarthritis: Data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2025Article
- Phenotypic variations in knee osteoarthritis: insights from MRI and radiographic comparisons.Skeletal radiology · 2025Article
- Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis.International journal of molecular sciences · 2025Review
- Integration of longitudinal load-bearing tissue MRI radiomics and neural network to predict knee osteoarthritis incidence.Journal of orthopaedic translation · 2025Article
- Frontal plane mechanical leg alignment estimation from knee x-rays using deep learning.Osteoarthritis and cartilage open · 2025Article
- Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative.PloS one · 2025Article
- Article
- Association of MRI-based knee osteoarthritis structural phenotypes with short-term structural progression and subsequent total knee replacement.Journal of orthopaedic surgery and research · 2024Article
- Relationship between Feline Knee Joint Osteoarthritis and Bone Mineral Density Quantified Using Computed Tomography and Computed Digital Absorptiometry.Animals : an open access journal from MDPI · 2024Article
- Investigating the relationship between radiographic joint space width loss and deep learning-derived magnetic resonance imaging-based cartilage thickness loss in the medial weight-bearing region of the tibiofemoral joint.Osteoarthritis and cartilage open · 2024Article
- Ultrasound Imaging in Knee Osteoarthritis: Current Role, Recent Advancements, and Future Perspectives.Journal of clinical medicine · 2024Review
- Identifying significant structural factors associated with knee pain severity in patients with osteoarthritis using machine learning.Scientific reports · 2024Article
- Approaches to optimize analyses of multidimensional ordinal MRI data in osteoarthritis research: A perspective.Osteoarthritis and cartilage open · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Currently, no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Past clinical trials have failed for several reasons, including the commonly applied definition of eligibility based on radiographic assessment of joint structure. In the context of precision medicine, finding the appropriate patient for a specific treatment approach will be of increasing relevance. Phenotypic stratification by use of imaging at the time of determining eligibility for clinical trials will be paramount and cannot be achieved using radiography alone. Furthermore, identification of joints at high risk of rapid progression of osteoarthritis is needed in order to enable a more efficient DMOAD trial design. In addition, joints at high risk of collapse need to be excluded at screening. The use of MRI might offer advantages over radiography in this context. Technological advances and simplified image assessment address many of the commonly perceived barriers to the application of MRI to assessment of eligibility for DMOAD clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.