ArticleJournal of the American Society of Nephrology : JASN2018
Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation.
Registry-linked trialOpen access · bronzeAbstract readEquivalence TrialMulticenter Study
In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04657562 (Development and Validation of New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma in CYP3A5 Expressors and Non-Expressors), which is not on this map. Cited by 100 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 6 pooled it
24.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma in CYP3A5 Expressors and Non-Expressors
Who cites it
100 citing papers in PubMed, 6 syntheses or guidelines pooled it, 241 citations in OpenAlex.
- Thai Transplant Care Practice Guideline on Immunosuppressive Therapy for Adult Kidney Transplantation.Nephrology (Carlton, Vic.) · 2026Guideline
- Delayed initiation or reduced initial dose of calcineurin-inhibitors for kidney transplant recipients at high risk of delayed graft function.The Cochrane database of systematic reviews · 2025Pooled it
- Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients.The Cochrane database of systematic reviews · 2024Pooled it
- Calcineurin and mTOR inhibitors in kidney transplantation: integrative metamodeling on transplant survival and kidney function.International urology and nephrology · 2024Pooled it
- Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Annals of transplantation · 2021Pooled it
- Target of rapamycin inhibitors (TOR-I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients.The Cochrane database of systematic reviews · 2019Pooled it
- Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial.Journal of the American Society of Nephrology : JASN · 2026Trial
- Effects of two immunosuppression regimens on T-lymphocyte subsets in elderly kidney transplant recipients.Frontiers in immunology · 2024Trial
- Role of SARS-CoV-2-specific memory B cells promoting immune protection after booster vaccination in solid organ transplantation.Frontiers in immunology · 2024Trial
- Trial
- Everolimus-facilitated calcineurin inhibitor reduction in Asian de novo kidney transplant recipients: 2-year results from the subgroup analysis of the TRANSFORM study.Clinical transplantation · 2021Trial
- Autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal: The randomized prospective, single-center, open-label TRITON study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Trial
- Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation.Scientific reports · 2020Trial
- Dose-Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men.Clinical and translational science · 2020Trial
- Trial
- AI-enabled clinical trials.Nature reviews bioengineering · 2026Article
- Everolimus-Involving Immunosuppression Attenuates Renal Interstitial Fibrosis Through Modulation of Mammalian Target of Rapamycin-Related Signal Transduction.International journal of molecular sciences · 2026Article
- Neutral impact of mTOR inhibitors on cardiovascular outcomes after kidney transplantation.Clinical kidney journal · 2026Article
- Sirolimus Versus Mycophenolate Mofetil in Simultaneous Pancreas-Kidney Transplantation: Impact on Urinary Tract Infection Rates.Journal of transplantation · 2026Article
- Vascular malformations: from genetics to therapeutics.EMBO molecular medicine · 2026Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
20 authors at 18 institutions in 11 countries.
Julio PascualDepartment of Nephrology, Hospital del Mar, Barcelona, Spain; JPascualSantos@parcdesalutmar.cat.
Stefan P BergerDepartment of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Oliver WitzkeDepartment of Infectious Diseases and Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Germany.
Helio TedescoNephrology Division, Hospital do Rim, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Shamkant MulgaonkarRenal and Pancreas Division, St. Barnabas Medical Center, Livingston, New Jersey.
Yasir QaziDivision of Nephrology, Keck School of Medicine Renal Transplant Program, University of Southern California, Los Angeles, California.
Steven ChadbanDepartment of Renal Medicine and Transplantation, Renal Medicine and Transplantation, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Federico OppenheimerDepartment of Nephrology and Renal Transplantation, Renal Transplant Unit, Hospital Clinic of Barcelona, Barcelona, Spain.
Claudia SommererDepartment of Nephrology, Heidelberg University Hospital, Heidelberg, Germany.
Rainer OberbauerDepartment of Nephrology and Dialysis, University Clinic for Internal Medicine III, Medical University Vienna, Vienna, Austria.
Yoshihiko WataraiDepartment of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya-City, Aich, Japan.
Christophe LegendreDepartment of Kidney Transplantation, Adult Transplantation Service, Paris Descartes University and Necker Hospital, Paris, France.
Franco CitterioDepartment of Surgery, Renal Transplantation, Catholic University, Rome, Italy.
Mitchell HenryDepartment of Surgery, The Comprehensive Transplant Center, The Ohio State University, Wexner Medical Center, Columbus, Ohio.
Titte R SrinivasDivision of Nephrology, Medical University of South Carolina, Mount Pleasant, South Carolina.
Wen-Lin LuoDepartment of Biometrics and Statistical Science, Novartis Pharmaceuticals, East Hanover, New Jersey.
AnaMaria MartiDepartment of Research and Development, Novartis Pharma AG, Basel, Switzerland; and.
Peter BernhardtDepartment of Research and Development, Novartis Pharma AG, Basel, Switzerland; and.
Flavio VincentiDepartment of Surgery, Kidney Transplant Service, University of California, San Francisco, California.
TRANSFORM Investigators
Novartis (Switzerland) · CHHeidelberg University · DEHospital Clínic de Barcelona · ESHospital Del Mar · ESHospital do Rim e Hipertensão · BRJapanese Red Cross Nagoya Daini Hospital · JPMedical University of South Carolina · USMedical University of Vienna · ATRoyal Prince Alfred Hospital · AUSaint Barnabas Medical Center · USThe Ohio State University Wexner Medical Center · USTris Pharma (United States) · USUniversità Cattolica del Sacro Cuore · ITUniversité Paris Cité · FRUniversity Medical Center Groningen · NLUniversity of California, San Francisco · USUniversity of Duisburg-Essen · DEUniversity of Southern California · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Kidney TransplantationAdrenal Cortex HormonesAdultAllograftsCalcineurin InhibitorsCyclosporineCytomegalovirus InfectionsEverolimusFemaleGlomerular Filtration RateGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsIntention to Treat AnalysisMaleAdrenal Cortex HormonesCalcineurin InhibitorsCyclosporineEverolimusImmunosuppressive AgentsMycophenolic AcidTacrolimuscalcineurin inhibitorefficacy grafteverolimusfunctionkidney transplantationrandomized
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04657562ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.