Evidence map›Paper›PMID 29752406›Full record

ArticleThe Journal of biological chemistry2018

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.

Elsa-Marie Treutlein, Katharina Kern, Andreas Weigert, Neda Tarighi, Claus-Dieter Schuh, Rolf M Nüsing, Yannick Schreiber, Nerea Ferreirós, Bernhard Brüne, Gerd Geisslinger and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Emerging role of macrophages in neuropathic pain.Journal of orthopaedic translation · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Signaling Pathway of PGEMediators of inflammation · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Novel Analgesics with Peripheral Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Elsa-Marie TreutleinFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Katharina KernFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Andreas Weigertthe Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60323 Frankfurt, Germany, and.
Neda TarighiFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Claus-Dieter SchuhFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Rolf M NüsingFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Yannick SchreiberFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Nerea FerreirósFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Bernhard Brünethe Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60323 Frankfurt, Germany, and.
Gerd GeisslingerFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Sandra PierreFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Klaus ScholichFrom the Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, University Hospital Frankfurt, 60590 Frankfurt, Germany, scholich@em.uni-frankfurt.de.ORCID 0000-0003-3744-0854
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostaglandin (PG) E

Indexed as

AnimalsCells, CulturedChemokine CCL2HyperalgesiaMaleMiceMice, Inbred C57BLMice, KnockoutNeuralgiaPain MeasurementPyrrolidinesReceptors, CCR2Receptors, Prostaglandin E, EP3 SubtypeSciatic NerveCcr2 protein, mouseChemokine CCL2INCB3344Ptger3 protein, mousePyrrolidinesReceptors, CCR2Receptors, Prostaglandin E, EP3 SubtypeCCL2chemokineG protein-coupled receptor (GPCR)mast cellsneuroinflammationneuropathic painpainperipheral neuronprostaglandinProstaglandin E2

Identifiers

PMID29752406
PMCPMC6016472
OpenAlexW2800917711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.