Evidence map›Paper›PMID 29752379›Full record

ArticleMolecular & cellular proteomics : MCP2018

Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin.

Julien Karim Malet, Francis Impens, Filipe Carvalho, Mélanie Anne Hamon, Pascale Cossart, David Ribet

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Fighting Cancer with Bacteria and Their Toxins.International journal of molecular sciences · 2021
    Review
  6. RevisitingMicroorganisms · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Pathogens (Basel, Switzerland) · 2020
    Review
  12. Review
  13. Article
  14. Mechanisms protecting host cells against bacterial pore-forming toxins.Cellular and molecular life sciences : CMLS · 2019
    Review
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Julien Karim MaletFrom the ‡Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France.
Francis Impens**VIB Center for Medical Biotechnology, B-9000 Ghent, Belgium.
Filipe CarvalhoFrom the ‡Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France.
Mélanie Anne Hamon¶¶Institut Pasteur, Unité Chromatine et infection, Paris, France.
Pascale CossartFrom the ‡Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France; pascale.cossart@pasteur.fr david.ribet@inserm.fr.
David RibetFrom the ‡Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France; pascale.cossart@pasteur.fr david.ribet@inserm.fr.ORCID 0000-0003-1175-6471
Inserm · FRInstitut Pasteur · FRUniversity College Ghent · BE

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Bacterial pathogens use various strategies to interfere with host cell functions. Among these strategies, bacteria modulate host gene transcription, thereby modifying the set of proteins synthetized by the infected cell. Bacteria can also target pre-existing host proteins and modulate their post-translational modifications or trigger their degradation. Analysis of protein levels variations in host cells during infection allows to integrate both transcriptional and post-transcriptional regulations induced by pathogens. Here, we focused on host proteome alterations induced by the toxin Listeriolysin O (LLO), secreted by the bacterial pathogen

Indexed as

Host-Pathogen InteractionsAnimalsBacterial ToxinsDown-RegulationEpithelial CellsHeat-Shock ProteinsHeLa CellsHemolysin ProteinsHep G2 CellsHumansMiceProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalProteomeRAW 264.7 CellsUbiquitinationBacterial ToxinsClostridium perfringens theta-toxinHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesProteasome Endopeptidase ComplexProteomeBacteriaCell biologyHost-Pathogen InteractionInfectious diseaseListeriaListeriolysin OPost-translational modificationsProtein DegradationShotgun proteomicsSILACTandem Mass SpectrometryToxinTranscriptional RegulationTranscriptomicsUbiquitin

Identifiers

PMID29752379
PMCPMC6072537
OpenAlexW2799405617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.