ArticleMolecular pharmacology2018
Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD.International journal of molecular sciences · 2025Article
- Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.bioRxiv : the preprint server for biology · 2025Article
- Hepatic AhR Activation by TCDD Induces Obesity and Steatosis via Hepatic Plasminogen Activator Inhibitor-1 (PAI-1).International journal of molecular sciences · 2025Article
- Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers.Cell genomics · 2025Article
- Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets.International journal of biological sciences · 2025Review
- An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver.Cellular and molecular gastroenterology and hepatology · 2025Article
- Dioxin-Induced PAI-1 Expression: A Novel Pathway to Pancreatic β-Cell Failure in Type 2 Diabetes.International journal of molecular sciences · 2024Article
- Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.Redox biology · 2024Article
- Aryl Hydrocarbon Receptor Involvement in the Sodium-Dependent Glutamate/Aspartate Transporter Regulation in Cerebellar Bergmann Glia Cells.ACS chemical neuroscience · 2024Article
- LipidSIM: Inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, Markov modeling framework.Metabolic engineering · 2024Article
- Cystine/Glutamate XcChemical research in toxicology · 2023Article
- Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.Scientific reports · 2023Article
- Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease.Experimental & molecular medicine · 2023Article
- Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2.Antioxidants (Basel, Switzerland) · 2022Review
- Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.International journal of molecular sciences · 2022Article
- Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?Acta pharmaceutica Sinica. B · 2021Review
- Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Rance NaultDepartments of Biochemistry and Molecular Biology (R.N., C.M.D., K.A.F., T.Z.) and Pharmacology and Toxicology (C.E.R.) and Institute for Integrative Toxicology (R.N., C.M.D., K.A.F., C.E.R., T.Z.), Michigan State University, East Lansing, Michigan.
Claire M DoskeyDepartments of Biochemistry and Molecular Biology (R.N., C.M.D., K.A.F., T.Z.) and Pharmacology and Toxicology (C.E.R.) and Institute for Integrative Toxicology (R.N., C.M.D., K.A.F., C.E.R., T.Z.), Michigan State University, East Lansing, Michigan.
Kelly A FaderDepartments of Biochemistry and Molecular Biology (R.N., C.M.D., K.A.F., T.Z.) and Pharmacology and Toxicology (C.E.R.) and Institute for Integrative Toxicology (R.N., C.M.D., K.A.F., C.E.R., T.Z.), Michigan State University, East Lansing, Michigan.
Cheryl E RockwellDepartments of Biochemistry and Molecular Biology (R.N., C.M.D., K.A.F., T.Z.) and Pharmacology and Toxicology (C.E.R.) and Institute for Integrative Toxicology (R.N., C.M.D., K.A.F., C.E.R., T.Z.), Michigan State University, East Lansing, Michigan.
Tim ZacharewskiDepartments of Biochemistry and Molecular Biology (R.N., C.M.D., K.A.F., T.Z.) and Pharmacology and Toxicology (C.E.R.) and Institute for Integrative Toxicology (R.N., C.M.D., K.A.F., C.E.R., T.Z.), Michigan State University, East Lansing, Michigan tzachare@msu.edu.
Michigan State University · US
Funding
VOLATILE ORGANIC CONTAMINANTS--QUANTIFYING THEIR MOVEMENT IN THE UNSATURATED ZONEP42ES004911 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Timothy R. Zacharewski · 1989 to 2026
$64.9MMULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3MThe role of Nrf2 in immune cell polarization and allergyR01ES024966 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ROCKWELL, CHERYL ELIZABETH · 2016 to 2020
$2.1MIntegrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5MCIHR DFS140386NIEHS NIH HHS P42 ES004911NIEHS NIH HHS R01 ES024966NIEHS NIH HHS T32 ES007255NIGMS NIH HHS T32 GM092715
Abstract
2,3,7,8-Tetrachlorodibenzo-
Indexed as
AnimalsAntioxidantsCells, CulturedChromatin ImmunoprecipitationGene Regulatory NetworksHepatocytesLiverMiceNF-E2-Related Factor 2Oxidative StressPolychlorinated DibenzodioxinsProtein BindingPyruvate KinaseReceptors, Aryl HydrocarbonSequence Analysis, RNAAntioxidantsNfe2l2 protein, mouseNF-E2-Related Factor 2Pkm protein, mousePolychlorinated DibenzodioxinsPyruvate KinaseReceptors, Aryl Hydrocarbon
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.