Evidence map›Paper›PMID 29752272›Full record

ArticleApplied and environmental microbiology2018

Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria.

Tijs J M van den Bosch, Kemin Tan, Andrzej Joachimiak, Cornelia U Welte

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. ISME communications · 2026
    Article
  4. Article
  5. A Switch from Latent to Typical Infection duringInternational journal of molecular sciences · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. The Microbial Diversity of Cabbage PestFrontiers in microbiology · 2020
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Tijs J M van den BoschDepartment of Environmental Microbiology, Institute of Water and Wetland Research, Radboud University, Nijmegen, The Netherlands.
Kemin TanMidwest Center for Structural Genomics and Structural Biology Center, Biosciences, Argonne National Laboratory, Lemont, Illinois, USA ktan@anl.gov c.welte@science.ru.nl.
Andrzej JoachimiakMidwest Center for Structural Genomics and Structural Biology Center, Biosciences, Argonne National Laboratory, Lemont, Illinois, USA.
Cornelia U WelteDepartment of Environmental Microbiology, Institute of Water and Wetland Research, Radboud University, Nijmegen, The Netherlands ktan@anl.gov c.welte@science.ru.nl.ORCID 0000-0002-1568-8878
Argonne National Laboratory · USRadboud University Nijmegen · NL

Funding

Midwest Center for Structural GenomicsU54GM094585 · NIGMS · UNIVERSITY OF CHICAGO · PI OTWINOWSKI, ZBYSZEK · 2010 to 2014
$33.7M
The Midwest Center for Structural Genomics - Community ResourceR24GM115586 · NIGMS · UNIVERSITY OF CHICAGO · PI JOACHIMIAK, ANDRZEJ · 2015 to 2017
$2.8M
NIGMS NIH HHS R24 GM115586NIGMS NIH HHS U54 GM094585
6 · The paper itself

Abstract

Isothiocyanates (ITCs) are produced by cruciferous plants to protect them against herbivores and infection by microbes. These compounds are of particular interest due to their antimicrobial and anticarcinogenic properties. The breakdown of ITCs in nature is catalyzed by isothiocyanate hydrolases (ITCases), a novel family within the metallo-β-lactamase (MBL)-fold superfamily of proteins.

Indexed as

Amino Acid SequenceAnimalsAnti-Bacterial AgentsBacteriabeta-LactamasesCatalytic DomainCloning, MolecularCrystallography, X-RayDipteraGastrointestinal MicrobiomeGene Expression Regulation, BacterialHydrolasesIsothiocyanatesModels, MolecularMolecular WeightPhylogenyAnti-Bacterial Agentsbeta-LactamasesHydrolasesIsothiocyanatesisothiocyanic acidisothiocyanate hydrolasemetallo-β-lactamase superfamilymultisubstrate enzyme assaySaxAX-ray crystallography

Identifiers

PMID29752272
PMCPMC6029094
OpenAlexW2802257737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.