Evidence map›Paper›PMID 29752062›Full record

ArticleImmunity2018

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.

Lauren B Rodda, Erick Lu, Mariko L Bennett, Caroline L Sokol, Xiaoming Wang, Sanjiv A Luther, Ben A Barres, Andrew D Luster, Chun Jimmie Ye, Jason G Cyster

Abstract read
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
268citing papers in PubMed, 1 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

268 citing papers in PubMed, 1 synthesis or guideline pooled it, 436 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
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  3. Review
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  7. Review
  8. Foxs1-mediated transformation of CD34EMBO molecular medicine · 2026
    Article
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  15. Review
  16. CCL19bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Fibroblast diversity within human gut-associated lymphoid tissues.The Journal of experimental medicine · 2026
    Article

208 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Lauren B RoddaHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Erick LuHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Mariko L BennettDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Caroline L SokolCenter for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Xiaoming WangDepartment of Immunology, Nanjing Medical University, Nanjing, China.
Sanjiv A LutherDepartment of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Ben A BarresDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew D LusterCenter for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Chun Jimmie YeInstitute for Human Genetics, Department of Epidemiology and Biostatistics, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Jason G CysterHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jason.cyster@ucsf.edu.
University of California, San Francisco · USMassachusetts General Hospital · USStanford University · USHoward Hughes Medical Institute · USNanjing Medical University · CNUniversity of Lausanne · CH

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Chemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6M
B LYMPHOCYTE MIGRATION AND HOMEOSTASISR01AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 1997 to 2026
$7.0M
Beta Lymphocyte Migration and HomeostasisR37AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 2002 to 2011
$3.2M
The CXCR3 Chemokine System in Cancer ImmunotherapyR01CA204028 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LUSTER, ANDREW D · 2017 to 2021
$1.9M
Chemokines and Lymphoid Tissue Organization and FunctionR37AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 2024 to 2026
$1.7M
The Role of Innate Immune Cell Trafficking in Th2 DifferentiationK08AI121421 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SOKOL, CAROLINE LAUREN · 2016 to 2020
$990k
Howard Hughes Medical InstituteNCI NIH HHS R01 CA204028NIAID NIH HHS K08 AI121421NIAID NIH HHS R01 AI040098NIAID NIH HHS R01 AI045073NIAID NIH HHS R37 AI040098NIAID NIH HHS R37 AI045073NIAID NIH HHS T32 AI007334NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the immune response. However, the full diversity of lymph node (LN) SCs remains undefined. Using droplet-based single-cell RNA sequencing, we identified nine peripheral LN non-endothelial SC clusters. Included are the established subsets, Ccl19

Indexed as

AnimalsChemokine CCL19Dendritic Cells, FollicularFemaleLymph NodesLymphoid TissueMice, Inbred C57BLSequence Analysis, RNASingle-Cell AnalysisStromal CellsTranscriptomeChemokine CCL19double negative cellfibroblastic reticular cellfollicular dendritic cellmarginal reticular cellperivascular cellsingle-cell RNA sequencingstromal cell

Identifiers

PMID29752062
PMCPMC5971117
OpenAlexW2801762127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.