ArticleSchizophrenia research2018
Age-related trajectories of social cognition in youth at clinical high risk for psychosis: An exploratory study.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Disentangling the Relationships Between the Clinical Symptoms of Schizophrenia Spectrum Disorders and Theory of Mind: A Meta-analysis.Schizophrenia bulletin · 2023Pooled it
- Implicit Mentalizing in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2022Pooled it
- Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.Schizophrenia bulletin · 2025Article
- The Interplay of Oxytocin and Attachment in Schizophrenic Patients: An fMRI Study.Brain sciences · 2023Article
- Metacognition, social cognition, and mentalizing in psychosis: are these distinct constructs when it comes to subjective experience or are we just splitting hairs?BMC psychiatry · 2021Review
- Social Dysfunction in Psychosis Is More Than a Matter of Misperception: Advances From the Study of Metacognition.Frontiers in psychology · 2021Review
- Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.Schizophrenia research · 2020Article
- Persons With Schizophrenia Misread Hemingway: A New Approach to Study Theory of Mind in Schizophrenia.Frontiers in psychiatry · 2020Article
- Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study.Schizophrenia bulletin · 2019Article
- A Mentalization-Informed Staging Approach to Clinical High Risk for Psychosis.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundClinical high risk (CHR) status is characterized by impairments in social cognition, but questions remain concerning their stability over development. In cross-sectional analysis of a large naturalistic sample, the current study examined whether those at CHR status show deviant trajectories for age-related change in social cognitive ability, and whether these trajectories are influenced by treatment history.
methodEmotion perception (EP) and theory of mind (ToM) were assessed in 675 CHR and 263 healthy comparison (HC) participants aged 12-35. Age effects in CHR were modeled against HC age-expected performance. Prior medication status was tested for interactions with age.
resultsCHR exhibited normal age trajectory for EP, but significantly lower slopes for ToM from age 17 onward. This effect was specific to stimuli exhibiting sarcasm and not to detection of lies. When treatment history was included in the model, age-trajectory appeared normal in CHR subjects previously prescribed both antipsychotics and antidepressant medication, although the blunted trajectory still characterized 80% of the sample. DISCUSSION: Cross-sectional analyses suggested that blunting of ToM in CHR develops in adolescence, while EP abilities were diminished evenly across the age range. Exploratory analyses of treatment history suggested that ToM was not affected, however, in CHRs with lifetime histories of both antipsychotic and antidepressant medications. Reduction in age-expected ToM ability may impair the ability of individuals at CHR to meet social developmental challenges in adolescence. Medication effects on social cognition deserve further study.
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