Evidence map›Paper›PMID 29751974›Full record

ReviewTrends in molecular medicine2018

Chemiexcitation and Its Implications for Disease.

Douglas E Brash, Leticia C P Goncalves, Etelvino J H Bechara, Excited-State Medicine Working Group

Open access · greenAbstract readReview
In one paragraph

Review in Trends in molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Quantum chemistry study on the feasibility of triplet-triplet energy transfer in the dark photosensitization of DNA.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Chemiexcitation: Mammalian Photochemistry in the DarkPhotochemistry and photobiology · 2023
    Review
  7. Article
  8. In-depth examination of hyperproliferative healing in two breeds ofAnimal models and experimental medicine · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Douglas E BrashDepartments of Therapeutic Radiology and Dermatology, and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8040, USA. Electronic address: douglas.brash@yale.edu.
Leticia C P GoncalvesDepartments of Therapeutic Radiology and Dermatology, and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8040, USA.
Etelvino J H BecharaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05513-970 SP, and Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Diadema, São Paulo 09972-270 SP, Brazil.
Excited-State Medicine Working Group
Universidade de São Paulo · BRYale Cancer Center · USYale University · US

Funding

Chemiexcitation: A New Mode of Skin DiseaseR01AR070851 · NIAMS · YALE UNIVERSITY · PI BRASH, DOUGLAS E · 2017 to 2020
$1.7M
NIAMS NIH HHS R01 AR070851
6 · The paper itself

Abstract

Quantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In invertebrates, chemiexcitation causes bioluminescence; in mammals, a higher-energy process involving melanin transfers energy to DNA without photons, creating the lethal and mutagenic cyclobutane pyrimidine dimer that can cause melanoma. This process is initiated by NO and O

Indexed as

Biochemical PhenomenaDisease SusceptibilityAnimalsHumanschemiexcitationdeafnessmacular degenerationmelaninParkinson’s diseasetriplet state

Identifiers

PMID29751974
PMCPMC5975183
OpenAlexW2802827744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.