ArticleCardiovascular diabetology2018
Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study.
Article in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis.Circulation. Genomic and precision medicine · 2023Article
- BMF-AS1/BMF Promotes Diabetic Vascular Calcification and Aging bothAging and disease · 2023Article
- Coronary calcium density in relation to coronary heart disease and cardiovascular disease in adults with diabetes or metabolic syndrome: the Multi-ethnic Study of Atherosclerosis (MESA).BMC cardiovascular disorders · 2022Article
- Investigation of expression of myocardial miR-126, miR-29a and miR-222 as a potential marker in STZ- induced diabetic rats following interval and continuous exercise training.Journal of diabetes and metabolic disorders · 2022Article
- Diabetic heart disease: A clinical update.World journal of diabetes · 2021Review
- Intensity of Glycemic Exposure in Early Adulthood and Target Organ Damage in Middle Age: The CARDIA Study.Frontiers in physiology · 2021Article
- Transcriptional Programming in Arteriosclerotic Disease: A Multifaceted Function of the Runx2 (Runt-Related Transcription Factor 2).Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- The systemic implication of novel non-statin therapies in cardiovascular diabetology: PCSK9 as a case model.Cardiovascular endocrinology & metabolism · 2020Review
- Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations.Medical physics · 2019Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundCoronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear.
methodsWe examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study. CAC density was calculated as mass divided by volume, and associations with incident all-cause and CVD mortality [median follow-up 10.2 years European Americans (n = 902, n = 286 deceased), 5.2 years African Americans (n = 552, n = 93 deceased)] were examined using Cox proportional hazards models, independently and in models adjusted for CAC volume.
resultsIn European Americans, CAC density, like Agatston score and volume, was consistently associated with increased risk of all-cause and CVD mortality (p ≤ 0.002) in models adjusted for age, sex, statin use, total cholesterol, HDL, systolic blood pressure, high blood pressure medication use, and current smoking. However, these associations were no longer significant when models were additionally adjusted for CAC volume. CAC density was not significantly associated with mortality, either alone or adjusted for CAC volume, in African Americans.
conclusionsCAC density is not associated with mortality independent from CAC volume in European Americans and African Americans with type 2 diabetes.
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