Evidence map›Paper›PMID 29751767›Full record

ArticleJournal of nanobiotechnology2018

Development of gold nanoparticles biosensor for ultrasensitive diagnosis of foot and mouth disease virus.

Mervat E Hamdy, Michele Del Carlo, Hussein A Hussein, Taher A Salah, Ayman H El-Deeb, Mohamed M Emara, Guilia Pezzoni, Dario Compagnone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
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  11. Development of gold nanoparticle-based biosensors for COVID-19 diagnosis.Beni-Suef University journal of basic and applied sciences · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Green chemistry and coronavirus.Sustainable chemistry and pharmacy · 2021
    Review
  17. Review
  18. Review
  19. Multifunctional FeNanomaterials (Basel, Switzerland) · 2020
    Article
  20. Green Synthesized Montmorillonite/Carrageenan/FeInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Mervat E HamdyDepartment of Biotechnology Animal Health Research Institute, Agriculture Research Centre, Giza, 12618, Egypt.
Michele Del CarloDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64023, Teramo, Italy.
Hussein A HusseinDepartment of Virology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. husvirol@cu.edu.eg.
Taher A SalahNanotechnology Research Centre, British University, Cairo, Egypt.
Ayman H El-DeebDepartment of Virology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Mohamed M EmaraDepartment of Virology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Guilia PezzoniDepartment of Biotechnology, Zooprofilattico Institute of Lombardy and Emilia Romagna (IZSLER), 25124, Brescia, Italy.
Dario CompagnoneDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64023, Teramo, Italy.
Cairo University · EGUniversity of Teramo · ITEgypt Nanotechnology Center · EGIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" · IT

Funding

Science and Technology Development Fund - Research Scientific Grant (STDF-RSG) 12718
6 · The paper itself

Abstract

backgroundNano-PCR is a recent tool that is used in viral diseases diagnosis. The technique depends on the fundamental effects of gold nanoparticles (AuNPs) and is considered a very effective and sensitive tool in the diagnosis of different diseases including viral diseases. Although several techniques are currently available to diagnose foot and mouth disease virus (FMDV), a highly sensitive, highly specific technique is needed for specific diagnosis of the disease. In the present work, a novel AuNPs biosensor has been designed using thiol-linked oligonucleotides that recognize the conserved 3D gene of FMDV.

resultsThe AuNPs-FMDV biosensor specifically recognizes RNA standards of FMDV, but not that of swine vesicular disease virus (SVDV) isolates. The analytical sensitivity of the AuNPs-FMDV biosensor was 10 copy number RNA standards in RT-PCR and 1 copy number RNA standard in real-time rRT-PCR with a 94.5% efficiency, 0.989 R

conclusionsThe AuNPs-FMDV biosensor presents in this study demonstrates a superior analytical and clinical performance for FMDV diagnosis. In addition, this biosensor has a simple workflow and accelerates epidemiological surveillance, hence, it is qualified as an efficient FMDV diagnosis tool for quarantine stations and farms particularly in FMDV endemic areas.

Indexed as

Biosensing TechniquesAnimalsCattleFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusGoldMetal NanoparticlesReal-Time Polymerase Chain ReactionReproducibility of ResultsSensitivity and SpecificityGoldAuNPs-FMDV biosensorDiagnosisrRT-PCR

Identifiers

PMID29751767
PMCPMC5946443
OpenAlexW2805528631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.