Evidence map›Paper›PMID 29751765›Full record

ArticleParticle and fibre toxicology2018

Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s).

Bendik C Brinchmann, Tonje Skuland, Mia H Rambøl, Krisztina Szoke, Jan E Brinchmann, Arno C Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Non-polar components in PMFrontiers in genetics · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
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  13. Review
  14. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
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  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bendik C BrinchmannDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Tonje SkulandDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Mia H RambølNorwegian Center for Stem Cell Research, Department of Immunology, Oslo University Hospital, Oslo, Norway.
Krisztina SzokeNorwegian Center for Stem Cell Research, Department of Immunology, Oslo University Hospital, Oslo, Norway.
Jan E BrinchmannNorwegian Center for Stem Cell Research, Department of Immunology, Oslo University Hospital, Oslo, Norway.
Arno C GutlebLuxembourg Institute of Science and Technology (LIST), Environmental Research and Innovation (ERIN) Department, Belvaux, Grand Duchy of Luxembourg.
Elisa MoschiniLuxembourg Institute of Science and Technology (LIST), Environmental Research and Innovation (ERIN) Department, Belvaux, Grand Duchy of Luxembourg.
Alena KubátováDepartment of Chemistry, University of North Dakota, Grand Forks, ND, USA.
Klara KukowskiDepartment of Chemistry, University of North Dakota, Grand Forks, ND, USA.
Eric Le FerrecInserm U1085, Institut de Recherche en Santé, Environnement, Travail (IRSET), Rennes, France.
Dominique Lagadic-GossmannInserm U1085, Institut de Recherche en Santé, Environnement, Travail (IRSET), Rennes, France.
Per E SchwarzeDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Marit LågDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Magne RefsnesDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Johan ØvrevikDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
Jørn A HolmeDepartment of Air Pollution and Noise, Domain of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. jorn.holme@fhi.no.ORCID 0000-0001-6085-5471

Funding

Norges Forskningsråd 228143
6 · The paper itself

Abstract

backgroundExposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and development of atherosclerosis. It is still debated how DEP and other inhaled PM can contribute to CVD. However, organic chemicals (OC) adhered to the particle surface, are considered central to many of the biological effects. In the present study, we have explored the ability of OC from DEP to reach the endothelium and trigger pro-inflammatory reactions, a central step on the path to atherosclerosis.

resultsExposure-relevant concentrations of DEP (0.12 μg/cm

conclusionLipophilic and semi-lipophilic chemicals seemed to detach from DEP, translocate through alveolar epithelial cells and trigger pro-inflammatory reactions in endothelial cells at exposure-relevant concentrations. These effects appeared to be triggered by AhR agonists, and involve PAR-2 signaling.

Indexed as

Cyclooxygenase 2CytokinesEndothelial CellsGene ExpressionHumansInflammationMatrix Metalloproteinase 1MicrovesselsNanoparticlesPolycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonSignal TransductionVehicle EmissionsCyclooxygenase 2CytokinesMatrix Metalloproteinase 1Polycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonVehicle Emissions3D tri-cultureAir pollutionAryl hydrocarbon receptorAtherosclerosisCardiovascular diseaseDiesel exhaust particlesEndothelial cellsInflammationOrganic compounds

Identifiers

PMID29751765
PMCPMC5948689

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.