Evidence map›Paper›PMID 29751614›Full record

Trial reportNutrients2018

Effects of Dietary Acute Tryptophan Depletion (ATD) on NPY Serum Levels in Healthy Adult Humans Whilst Controlling for Methionine Supply-A Pilot Study.

Janice W Y Wong, Hugo A E Morandini, Vita L S Dingerkus, Tilman J Gaber, Kevin C Runions, Pradeep Rao, Simone Mahfouda, Katrin Helmbold, Sarah Bubenzer-Busch, Rebecca Koenemann and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Janice W Y WongCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. janice.wong@telethonkids.org.au.
Hugo A E MorandiniCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. hugo.morandini@health.wa.gov.au.
Vita L S DingerkusAcute Child and Adolescent Mental Health Services (CAMHS), Department of Health, 6009 Perth, Australia. vita.dingerkus@rwth-aachen.de.
Tilman J GaberClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University Hospital, 52074 Aachen, Germany. tilman.gaber@posteo.de.
Kevin C RunionsCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. kevin.runions@health.wa.gov.au.
Pradeep RaoCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. pradeep.rao@health.wa.gov.au.ORCID 0000-0002-5637-7769
Simone MahfoudaCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. simone.mahfouda@telethonkids.org.au.
Katrin HelmboldClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University Hospital, 52074 Aachen, Germany. katrin.helmbold@gmail.com.
Sarah Bubenzer-BuschClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University Hospital, 52074 Aachen, Germany. sarah-busch@outlook.com.
Rebecca KoenemannClinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University Hospital, 52074 Aachen, Germany. becci.koe@gmx.de.
Richard M StewartCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. richard.stewart@health.wa.gov.au.
Florian D ZepfCentre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, School of Medicine, Division of Psychiatry and Clinical Neurosciences and Division of Paediatrics and Child Health, The University of Western Australia, 6009 Perth, Australia. florian.zepf@uwa.edu.au.
RWTH Aachen University · DEThe Kids Research Institute Australia · AUThe University of Western Australia · AUTriemli Hospital · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous serotonin (5-HT) can influence behaviour and neuropsychiatric disorders. Evidence from animal models suggest that lowered levels of neuropeptide Y (NPY) may have similar effects, although it is currently unknown whether decreased central nervous 5-HT impact NPY concentrations. Given that the production of NPY is dependent on the essential amino acid methionine (MET), it is imperative to account for the presence of MET in such investigations. Hence, this study sought to examine the effects of acute tryptophan depletion (ATD; a dietary procedure that temporarily lowers central nervous 5-HT synthesis) on serum concentrations of NPY, whilst using the potential renal acid load indicator (PRAL) to control for levels of MET. In a double-blind repeated measures design, 24 adult humans randomly received an AA-load lacking in TRP (ATD) on one occasion, and a balanced control mixture with TRP (BAL) on a second occasion, both with a PRAL of nearly 47.3 mEq of MET. Blood samples were obtained at 90, 180, and 240 min after each of the AA challenges. ATD, and therefore, diminished substrate availability for brain 5-HT synthesis did not lead to significant changes in serum NPY concentrations over time, compared to BAL, under an acute acidotic stimulus.

Indexed as

AdultBody Mass IndexBrainDietDouble-Blind MethodFemaleHumansMaleMethionineNeuropeptide YPilot ProjectsSerotoninTryptophanYoung AdultMethionineNeuropeptide YSerotoninTryptophanacid base statusmental healthmethionineneuropeptide Yserotonin depletiontryptophan

Identifiers

PMID29751614
PMCPMC5986474
OpenAlexW2800445929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.