ReviewJournal of clinical medicine2018
The Relationship between Sleep Problems, Neurobiological Alterations, Core Symptoms of Autism Spectrum Disorder, and Psychiatric Comorbidities.
Review in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Correlations between sleep problems, core symptoms, and behavioral problems in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.European child & adolescent psychiatry · 2024Pooled it
- Impact of COVID-19 pandemic on sleep in children and adolescents: a systematic review and meta-analysis.Sleep medicine · 2021Pooled it
- Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies.Evidence-based mental health · 2018Pooled it
- Association Between Toe Walking and Repetitive Behaviors in Children with Autism Spectrum Disorder: A Cross-Sectional Phenotypic Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats.Molecular psychiatry · 2026Article
- Understanding the Complexity of Sleep Disturbances in ASD: From Mechanisms to Management.Diagnostics (Basel, Switzerland) · 2026Review
- Comparative accuracy of sleep disturbance questionnaires in children with autism spectrum disorder: a receiver operating characteristic study.BMJ paediatrics open · 2026Observational
- Article
- Risk factors and a prediction model for ASD symptoms in Chinese preschool children.Frontiers in psychiatry · 2026Article
- Sleep problems in autistic children and adolescents: an age-stratified approach.Frontiers in psychology · 2026Article
- Insomnia severity and its association with gaming behavior and perceived health in autistic adults.BMC psychology · 2025Article
- Dimensional Validation of the Italian Revised Version of the Children's Sleep Habits Questionnaire (CSHQ-r) for Children and Adolescents with ASD.Journal of autism and developmental disorders · 2025Article
- Sleep Disturbances and Co-sleeping in Italian Children and Adolescents with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2025Article
- Assessment of Sleep Habit and Oral Habits in Children with Autism Spectrum Disorder and Attention-deficit Hyperactivity Disorder: A Cross-sectional Study.International journal of clinical pediatric dentistry · 2025Article
- Sleep Disturbances and Behavioral Problems in Children and Adolescents with Autism Spectrum Disorder-A Systematic Review.Clinics and practice · 2025Review
- Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies.Brain sciences · 2025Review
- Association Between Sleep Disturbance and Behavioral Feeding Problems in Children and Adolescents with Autism Spectrum Disorder.Diseases (Basel, Switzerland) · 2025Article
- Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan.Molecular neurobiology · 2025Review
- Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.European journal of pediatrics · 2025Observational
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with Autism Spectrum Disorder (ASD) are at an increased risk for sleep disturbances, and studies indicate that between 50 and 80% of children with ASD experience sleep problems. These problems increase parental stress and adversely affect family quality of life. Studies have also suggested that sleep disturbances may increase behavioral problems in this clinical population. Although understanding the causes of sleep disorders in ASD is a clinical priority, the causal relationship between these two conditions remains unclear. Given the complex nature of ASD, the etiology of sleep problems in this clinical population is probably multi-factorial. In this overview, we discuss in detail three possible etiological explanations of sleep problems in ASD that can all contribute to the high rate of these symptoms in ASD. Specifically, we examine how neurobiological alterations, genetic mutations, and disrupted sleep architecture can cause sleep problems in individuals with ASD. We also discuss how sleep problems may be a direct result of core symptoms of ASD. Finally, a detailed examination of the relationship between sleep problems and associated clinical features and psychiatric comorbidities in individuals with ASD is described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.