ArticleNutrients2018
Neurocognitive Disorders and Dehydration in Older Patients: Clinical Experience Supports the Hydromolecular Hypothesis of Dementia.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice.Nature communications · 2026Article
- Prevalence of low-intake dehydration in hospitalised older adults: systematic review and meta-analysis.BMJ public health · 2026Article
- The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits.bioRxiv : the preprint server for biology · 2025Article
- Hydration Status in Geriatric Patients-Subjective Impression or Objective Parameter? The Hydr-Age-Study.Nutrients · 2025Observational
- Dose-dependent evaluation of chronic oleocanthal on metabolic phenotypes and organ toxicity in 5xFAD mice.Pharmacological research. Natural products · 2025Article
- Hydration Strategies in Older Adults.Nutrients · 2025Review
- Predicting dementia in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The Emerging Role of Water Loss in Dog Aging.Cells · 2025Review
- Daily fluid intake and brain amyloid deposition: A cohort study.Journal of Alzheimer's disease : JAD · 2025Article
- ARCH: Large-scale knowledge graph via aggregated narrative codified health records analysis.Journal of biomedical informatics · 2025Article
- Effect of fluid intake on cognitive function in older individuals: A prospective study.PloS one · 2025Article
- The relationship between dehydration and etiologic subtypes of major neurocognitive disorder in older patients.European geriatric medicine · 2024Article
- Heat Exposure and Dementia-Related Mortality in China.JAMA network open · 2024Article
- Prevention, Assessment, and Management of Malnutrition in Older Adults with Early Stages of Cognitive Disorders.Nutrients · 2024Review
- Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation.Nutrients · 2023Article
- Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants.Neurology · 2023Article
- Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study.BMC medicine · 2023Article
- Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
- Chronic Dehydration in Nursing Home Residents.Nutrients · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit were evaluated with the Mini-Mental State Examination (MMSE), 21-Item Hamilton Depression Rating Scale (HDRS-21), Activities of Daily Living (ADL), Instrumental-ADL (IADL), Mini Nutritional Assessment (MNA), Exton-Smith Scale (ESS), and Cumulative Illness Rating Scale (CIRS). For each patient, the equation for serum osmolality developed by Khajuria and Krahn was applied. Five hundred and seventy-one patients had cognitive decline and/or depression mood (CD-DM) and 520 did not have CD-DM (control group). Patients with CD-DM were less likely to be male (
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