ArticleEuropean journal of neurology2018
Inflammation, edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages.
Article in European journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis.Critical care (London, England) · 2024Pooled it
- The association between perihaematomal oedema and functional outcome after spontaneous intracerebral haemorrhage: A systematic review and meta-analysis.European stroke journal · 2023Pooled it
- Advances in Stereotactic Hematoma Evacuation for Hypertensive Intracerebral Hemorrhage and the Value of Multimodal Monitoring.Cerebrovascular diseases (Basel, Switzerland) · 2026Review
- Early Dynamics of Body Temperature in Acute Stroke: Insights into Outcomes and Management.Journal of clinical medicine · 2026Article
- Functional outcome prediction across multiple timescales intracerebral hemorrhage using a radiomics model.European journal of radiology open · 2026Article
- Escalation of care in a patient presenting with acute altered mental state.Singapore medical journal · 2026Article
- Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section.Neurological research and practice · 2025Article
- How far are we from bringing intensive care bundle for intracerebral hemorrhage into the real-world setting? A 5-year population based-study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Postoperative fever and clinical outcomes after endoscopic surgery for spontaneous intracerebral hemorrhage: a retrospective database study.BMC neurology · 2024Article
- Influence of bundled care treatment on functional outcome in patients with intracerebral hemorrhage.Frontiers in neurology · 2024Article
- Minimally invasive puncture combined with a high frequency of urokinase therapy improves outcomes in patients with HICH.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Early fever in patients with primary intracerebral hemorrhage is associated with worse long-term functional outcomes: a prospective study.BMC neurology · 2023Article
- A comparison of random survival forest and Cox regression for prediction of mortality in patients with hemorrhagic stroke.BMC medical informatics and decision making · 2023Article
- Determinants of acute and subacute case-fatality in elderly patients with hypertensive intracerebral hemorrhage.Heliyon · 2023Article
- Fever burden within 24 h after hematoma evacuation predicts early neurological deterioration in patients with intracerebral hemorrhage: a retrospective analysis.Frontiers in neurology · 2023Article
- Construction of a nomogram to reveal the prognostic benefit of spontaneous intracranial hemorrhage among Chinese adults: a population-based study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Development and validation of a nomogram to predict the 30-day mortality risk of patients with intracerebral hemorrhage.Frontiers in neuroscience · 2022Article
- Cerebral small vessel disease and perihematomal edema formation in spontaneous intracerebral hemorrhage.Frontiers in neurology · 2022Article
- sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage.Stroke and vascular neurology · 2021Observational
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH etiology) that influence the poor outcome associated with hyperthermia and ICH. We also tried to identify potential mechanisms involved in hyperthermia during ICH.
methodsWe conducted a retrospective study enrolling patients with non-traumatic ICH from a prospective registry. We used logistic regression models to analyze the influence of hyperthermia in relation to different inflammatory and endothelial dysfunction markers, hematoma growth and edema volume in hypertensive and non-hypertensive patients with ICH.
resultsWe included 887 patients with ICH (433 hypertensive, 50 amyloid, 117 by anticoagulants and 287 with other causes). Patients with hypertensive ICH showed the highest body temperature (37.5 ± 0.8°C) as well as the maximum increase in temperature (0.9 ± 0.1°C) within the first 24 h. Patients with ICH of hypertensive etiologic origin, who presented hyperthermia, showed a 5.3-fold higher risk of a poor outcome at 3 months. We found a positive relationship (r = 0.717, P < 0.0001) between edema volume and hyperthermia during the first 24 h but only in patients with ICH of hypertensive etiologic origin. This relationship seems to be mediated by inflammatory markers.
conclusionOur data suggest that hyperthermia, together with inflammation and edema, is associated with poor outcome only in ICH of hypertensive etiology.
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