Evidence map›Paper›PMID 29750857›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Residue-Specific Dynamics and Local Environmental Changes in Aβ40 Oligomer and Fibril Formation.

Haiyang Liu, Clifford Morris, Richard Lantz, Thomas W Kent, Esmail A Elbassal, Ewa P Wojcikiewicz, Deguo Du

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Identification of Catechins' Binding Sites in Monomeric AInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Mucin-TypeFrontiers in chemistry · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haiyang LiuDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Clifford MorrisDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Richard LantzDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Thomas W KentDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Esmail A ElbassalDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Ewa P WojcikiewiczDepartment of Biomedical Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Deguo DuDepartment of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.ORCID 0000-0002-8701-8208

Funding

Role of the N-terminal Region in Abeta Oligomer and Fibril FormationR15GM116006 · NIGMS · FLORIDA ATLANTIC UNIVERSITY · PI DU, DEGUO · 2015 to 2020
$735k
NIGMS NIH HHS R15 GM116006
6 · The paper itself

Abstract

Elucidating local dynamics of protein aggregation is crucial for understanding the mechanistic details of protein amyloidogenesis. Herein, we studied the residue-specific dynamics and local environmental changes of Aβ40 along the course of aggregation by using para-cyanophenylalanine (Phe

Indexed as

AmyloidAmyloid beta-PeptidesFluorescent DyesHydrophobic and Hydrophilic InteractionsKineticsMutagenesisPeptide FragmentsPhenylalanineProtein AggregatesSpectrometry, FluorescenceAmyloidAmyloid beta-Peptidesamyloid beta-protein (1-40)Fluorescent DyesPeptide FragmentsPhenylalanineProtein Aggregatesaggregationamyloid-βlocal dynamicsoligomersunnatural amino acids

Identifiers

PMID29750857
PMCPMC6028940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.