SynthesisPloS one2018
Guidelines for safe handling of hazardous drugs: A systematic review.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Global Cancer Nurse's Experiences and Perceptions of Potential Occupational Exposure to Cytotoxic Drugs: Mixed Method Systematic Review With Framework Synthesis.Journal of clinical nursing · 2024Pooled it
- Occupational Health of Health-Care Workers with Overnutrition: Scoping Review with Meta-Analysis.Nutrients · 2023Pooled it
- Computer programs used in the field of hospital pharmacy for the management of dangerous drugs: systematic review of literature.Frontiers in public health · 2023Pooled it
- Compliance and Adherence to Enteral Nutrition Treatment in Adults: A Systematic Review.Nutrients · 2019Pooled it
- Administering Antineoplastic Parenteral Cancer Therapy in the Patient's Home: Perspectives of Oncology Nurses-A Descriptive Qualitative Study.Nursing open · 2026Article
- Educational intervention effects on nurses' knowledge, attitudes, and practice toward handling cytotoxic drugs in their workplace.BMC nursing · 2025Article
- Health Effects of Ergonomics and Personal Protective Equipment on Chemotherapy Professionals.Current oncology (Toronto, Ont.) · 2025Review
- Population interest in and adequacy of the information on the safety of antineoplastic agents in the Spanish edition of Wikipedia.PloS one · 2025Article
- Longitudinal evaluation of environmental contamination with hazardous drugs by surface wipe sampling.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2024Article
- Quality assurance standards and their use in the preparation of parenteral systemic anticancer therapy products in healthcare establishments: a scoping review.European journal of hospital pharmacy : science and practice · 2024Article
- Inhaled Medicines for Targeting Non-Small Cell Lung Cancer.Pharmaceutics · 2023Review
- Hazardous medicinal products.European journal of hospital pharmacy : science and practice · 2023Article
- Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination.International journal of environmental research and public health · 2023Article
- Validation of chemotherapy drug vapor containment of an air cleaning closed-system drug transfer device.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2022Article
- A simple approach to assess the cancer risk of occupational exposure to genotoxic drugs in healthcare settings.Journal of occupational medicine and toxicology (London, England) · 2022Article
- Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems.Frontiers in microbiology · 2022Review
- Improving nurses' performance in the safe handling of antineoplastic agents: a quasi-experimental study.BMC nursing · 2021Article
- Optimisation of maintenance in delivery systems for cytostatic medicines.BMC health services research · 2021Article
- An Improved LC-MS/MS Method for the Analysis of Thirteen Cytostatics on Workplace Surfaces.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Pelvic floor: vaginal or caesarean delivery? A review of systematic reviews.International urogynecology journal · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the scientific literature related to the safe handling of hazardous drugs (HDs).
methodCritical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017.
resultsIn total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39.3%) documents related to recommendations about HDs; 27 (44.3%) about antineoplastic agents, and 10 (33.3%) about other types of substances (monoclonal antibodies, gene medicine and other chemical and biological agents). In 14 (23.3%) guides, all the stages in the manipulation process involving a risk due to exposure were considered. Only one guide addressed all stages of the handling process of HDs (including stages with and without the risk of exposure). The most described stages were drug preparation (41 guides, 67.2%), staff training and/or patient education (38 guides, 62.3%), and administration (37 guides, 60.7%). No standardized informatics system was found that ensured quality management, traceability and minimization of the risks associated with these drugs.
conclusionsMost of the analysed guidelines limit their recommendations to the manipulation of antineoplastics. The most frequently described activities were preparation, training, and administration. It would be convenient to apply ICTs (Information and Communications Technologies) to manage processes involving HDs in a more complete and simpler fashion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.