ArticleMolecular medicine reports2018
Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial.Scientific reports · 2019Trial
- Porphyromonas gingivalis and Scardovia wiggsiae promote neutrophil-induced lung epithelial cell apoptosis and emphysema.Journal of periodontology · 2026Article
- Microbiological Analysis Following Periodontal Treatment in Individuals with Bronchiectasis.Microorganisms · 2026Article
- Impact of emerging and re-emerging viral infections on periodontitis progression.Archives of microbiology · 2025Review
- Periodontal Pathobionts and Respiratory Diseases: Mechanisms of Interaction and Implications for Interdisciplinary Care.Biomedicines · 2025Review
- Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen Porphyromonas gingivalis.Nucleic acids research · 2025Article
- Synergistic effects ofFrontiers in cellular and infection microbiology · 2025Article
- Respiratory tract barrier dysfunction in viral-bacterial co-infection cases.The Japanese dental science review · 2024Review
- Inhibition of SARS-CoV-2 infection byMicrobiology spectrum · 2024Article
- Cinnamaldehyde Protects againstInternational journal of molecular sciences · 2024Article
- Article
- Advances in the relationship between periodontopathogens and respiratory diseases (Review).Molecular medicine reports · 2024Review
- PeriodontopathogensPathogens (Basel, Switzerland) · 2023Review
- A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced byArchives of Razi Institute · 2023Review
- Characterizing the microbiota of cleft lip and palate patients: a comprehensive review.Frontiers in cellular and infection microbiology · 2023Review
- Associations and recovery dynamics of the nasopharyngeal microbiota during influenza-like illness in the aging population.Scientific reports · 2022Article
- Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation.The Japanese dental science review · 2021Review
- A potential therapeutic strategy for prostatic disease by targeting the oral microbiome.Medicinal research reviews · 2021Review
- The Impact of Oral Health on Respiratory Viral Infection.Dentistry journal · 2021Review
- Trypsin-Like Activity in Oral Cavity Is Associated with Risk of Fever Onset in Older Residents of Nursing Homes: An 8-Month Longitudinal Prospective Cohort Pilot Study.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the effects of Porphyromonas gingivalis (P. gingivalis) on inflammatory cytokine and nitic oxide (NO) production in lung epithelial cells infected with H1N1, and the underlying mechanisms. Lung epithelial cells were co‑infected with P. gingivalis and H1N1. The concentrations of tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6 were detected via an ELISA, and the concentration of NO was detected by the nitrate reductive enzymatic method at 4, 8, 12 and 24 h following infection. The expression levels of inducible NO synthase (iNOS) was detected by western blotting. The apoptotic rate of lung epithelial cells was detected by flow cytometry. The relative protein expression levels of B‑cell lymphoma‑2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and caspase‑3 in lung epithelial cells were detected by western blotting. Compared with the control group, the concentration of the inflammatory cytokines TNF‑α, IL‑1β and IL‑6 exhibited a significant increase (P<0.05) in the viral‑infected, bacterial‑infected and co‑infected groups. The concentration of NO also increased significantly (P<0.05), along with the rise in the expression levels of iNOS (P<0.05) and the increase in the apoptosis rate of lung epithelial cells (P<0.05). The relative expression levels of caspase‑3 and Bax proteins were increased significantly in the viral‑ and bacterial‑infected groups when compared with the control. The relative expression levels of Bcl‑2 protein exhibited a significant decrease in lung epithelial cells following the co‑infection with P. gingivalis and H1N1 compared with the control (P<0.05). The results of the present study revealed that the combination of P. gingivalis and H1N1 infection in lung epithelial cells may promote the production of inflammatory cytokines and increase NO production, leading to increased levels of apoptosis in lung epithelial cells via the Bcl‑2/Bax/caspase‑3 signaling pathway.
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