ArticleScience advances2018
3D printing of a wearable personalized oral delivery device: A first-in-human study.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- Review
- Artificial Intelligence Revolution in Pharmaceutical Sciences : Advancements, Clinical Impacts, and Applications.Current pharmaceutical biotechnology · 2026Review
- Research progress of 3D printing technology in the field of oral materials.Pharmaceutical science advances · 2025Review
- Prolonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment.Pharmaceutics · 2025Article
- A Review on 3D-Printed Miniaturized Devices for Point-of-Care-Testing Applications.Biosensors · 2025Review
- Innovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery.International journal of molecular sciences · 2025Review
- Impact Absorption Power of Polyolefin Fused Filament Fabrication 3D-Printed Sports Mouthguards: In Vitro Study.Dental traumatology : official publication of International Association for Dental Traumatology · 2025Article
- 3D printed spiral tube-like cellulose scaffold for oral delivery of probiotics.Science advances · 2024Article
- A coating machine for coating filaments with bioactive nanomaterials for extrusion 3D printing.Heliyon · 2024Article
- A scientometric and visualization analysis of 3D printing scaffolds for vascularized bone tissue engineering over the last decade.Regenerative therapy · 2024Review
- 3D Printed Materials for Permanent Restorations in Indirect Restorative and Prosthetic Dentistry: A Critical Review of the Literature.Materials (Basel, Switzerland) · 2024Review
- Excipients in Pharmaceutical Additive Manufacturing: A Comprehensive Exploration of Polymeric Material Selection for Enhanced 3D Printing.Pharmaceutics · 2024Review
- 3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management.Current drug delivery · 2024Review
- Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review.International journal of pharmaceutics: X · 2023Article
- Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.Nano-micro letters · 2023Review
- Fluoride Release and Rechargeability of Poly(lactic acid) Composites with Glass Ionomer Cement.Polymers · 2023Article
- Self-Standing 3D-Printed PEGDA-PANIs Electroconductive Hydrogel Composites for pH Monitoring.Gels (Basel, Switzerland) · 2023Article
- Practical Application of 3D Printing for Pharmaceuticals in Hospitals and Pharmacies.Pharmaceutics · 2023Review
- Study and Characterization of Polyvinyl Alcohol-Based Formulations for 3D Printlets Obtained via Fused Deposition Modeling.Pharmaceutics · 2023Article
- Ultrasound-trigged micro/nanorobots for biomedical applications.Smart medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the burgeoning interest in three-dimensional (3D) printing for the manufacture of customizable oral dosage formulations, a U.S. Food and Drug Administration-approved tablet notwithstanding, the full potential of 3D printing in pharmaceutical sciences has not been realized. In particular, 3D-printed drug-eluting devices offer the possibility for personalization in terms of shape, size, and architecture, but their clinical applications have remained relatively unexplored. We used 3D printing to manufacture a tailored oral drug delivery device with customizable design and tunable release rates in the form of a mouthguard and, subsequently, evaluated the performance of this system in the native setting in a first-in-human study. Our proof-of-concept work demonstrates the immense potential of 3D printing as a platform for the development and translation of next-generation drug delivery devices for personalized therapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.