Evidence map›Paper›PMID 29750184›Full record

ArticleInternational journal of cardiology. Heart & vasculature2018

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.

Justin Shenje, Rachel P Lai, Ian L Ross, Bongani M Mayosi, Robert J Wilkinson, Mpiko Ntsekhe, Katalin A Wilkinson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Use of Corticosteroids in Patients With Pleural and Pericardial Tuberculosis.Journal of community hospital internal medicine perspectives · 2025
    Review
  4. Article
  5. Article
  6. T cell responses toVaccine: X · 2022
    Article
  7. Review
  8. Targeting inflammatory citokines to prevent constriction in tuberculous pericarditis and beyond?International journal of cardiology. Heart & vasculature · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Justin ShenjeThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
Rachel P LaiThe Francis Crick Institute, NW1 2AT London, United Kingdom.
Ian L RossThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
Bongani M MayosiThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
Robert J WilkinsonThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
Mpiko NtsekheThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
Katalin A WilkinsonThe Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.
University of Cape Town · ZAThe Francis Crick Institute · GB

Funding

Medical Research Council MC_U117588499Medical Research Council MR/R008922/1
6 · The paper itself

Abstract

backgroundPericardial disorders are a common cause of heart disease, and the most common cause of pericarditis in developing countries is tuberculous (TB) pericarditis. It has been shown that prednisolone added to standard anti-TB therapy leads to a lower rate of constrictive pericarditis. We conducted a pilot study to evaluate the effect of adjunctive prednisolone treatment on the concentration of inflammatory markers in pericardial tuberculosis, in order to inform immunological mechanisms at the disease site.

methodsPericardial fluid, plasma and saliva samples were collected from fourteen patients with pericardial tuberculosis, at multiple time points. Inflammatory markers were measured using multiplex luminex analysis and ELISA.

resultsIn samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours.

conclusionMonitoring the early effect of adjunctive immunotherapy in plasma or saliva is a possibility in pericarditis.

Indexed as

HIVPericarditisSteroidsTreatment monitoringTuberculosis

Identifiers

PMID29750184
PMCPMC5941241
OpenAlexW2766882598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.