Evidence map›Paper›PMID 29750180›Full record

ArticleInternational journal of cardiology. Heart & vasculature2018

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events.

William J Phillips, Christopher Johnson, Angeline Law, Michele Turek, Alex R Small, Joao R Inacio, Susan Dent, Terrence Ruddy, Rob S Beanlands, Benjamin J W Chow and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Asparagine endopeptidase prompts breast cancer-related pericardial calcification by regulating IGF2 and integrin αvβ5.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Coronary Artery Calcifications and Cardiac Risk After Radiation Therapy for Stage III Lung Cancer.International journal of radiation oncology, biology, physics · 2022
    Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

William J PhillipsUniversity of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada.
Christopher JohnsonUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Angeline LawUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Michele TurekUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Alex R SmallUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Joao R InacioDepartment of Radiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Susan DentDepartment of Medicine (Oncology), Ottawa, Ontario, Canada.
Terrence RuddyUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Rob S BeanlandsUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Benjamin J W ChowUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
Gary R SmallUniversity of Ottawa, Department of Medicine (Division of Cardiology), Ottawa, Ontario, Canada.
University of Ottawa · CAOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe identification of coronary artery calcification (CAC) detected coincidentally on chest CT exams could assist in cardiovascular risk assessment but may not be reported consistently on clinical studies. Cardiovascular risk factor stratification is important to predict short term cardiac events during cancer therapy and long term cardiac event free survival in cancer patients. We sought to determine the prevalence of CAC and clinical reporting rates in a cohort of cancer patients at high risk of cancer therapy related cardiac events.

methods408 Breast cancer patients who were referred to a cardiac oncology clinic were screened. Inclusion criteria included having had a CT chest and the absence of known coronary disease. Among those screened 263 patients were included in the study.

resultsCAC was identified in 70 patients (26%). CAC was reported in 18% of studies. The reporting rates of CAC increased with the extent of coronary calcification (

conclusionsCAC was commonly detected on chest CT studies in this observational study of breast cancer patients at high risk of cardiac oncology events. The presence of CAC was often not reported clinically but reporting rates have increased over time. Recent SCCT/STR guidelines recommend reporting the presence of CAC on routine chest CT scans in recognition of the importance of CAC as a predictor of cardiovascular events. Reporting of CAC on chest CTs may help to further risk stratify breast cancer patients and improve cardiovascular outcomes in this vulnerable population.

Indexed as

Cardiac oncologyCoronary calcification and chest CT

Identifiers

PMID29750180
PMCPMC5941242
OpenAlexW2790719921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.